Sonrotoclax
Drug Detail

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Drug Name Sonrotoclax
Trade Name Beqalzi
Synonyms BGB 11417|BGB11417|BGB-11417
Drug Descriptions

Beqalzi (sonrotoclax) selectively inhibits Bcl2, which potentially leads to decreased tumor cell proliferation and inhibition of tumor growth (Cancer Res 2020;80(16 Suppl):Abstract nr 3077). Beqalzi (sonrotoclax) is FDA-approved for use in patients with relapsed or refractory mantle cell lymphoma (FDA.gov).

DrugClasses BCL2 inhibitor 29
CAS Registry Number NA
NCIT ID C175489

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Posaconazole + Sonrotoclax Azacitidine Posaconazole Sonrotoclax 0 0
Azacitidine + Sonrotoclax Azacitidine Sonrotoclax 0 1
BGB-16673 + Sonrotoclax BGB-16673 Sonrotoclax 0 2
Carfilzomib + Dexamethasone + Sonrotoclax Carfilzomib Dexamethasone Sonrotoclax 0 1
Daratumumab + Dexamethasone + Sonrotoclax Daratumumab Dexamethasone Sonrotoclax 0 1
Dexamethasone + Pomalidomide + Sonrotoclax Dexamethasone Pomalidomide Sonrotoclax 0 1
Dexamethasone + Sonrotoclax Dexamethasone Sonrotoclax 0 1
Obinutuzumab + Sonrotoclax Obinutuzumab Sonrotoclax 0 1
Obinutuzumab + Sonrotoclax + Zanubrutinib Obinutuzumab Sonrotoclax Zanubrutinib 0 2
Rituximab + Sonrotoclax Rituximab Sonrotoclax 0 2
Rituximab + Sonrotoclax + Zanubrutinib Rituximab Sonrotoclax Zanubrutinib 0 1
Sonrotoclax Sonrotoclax 0 4
Sonrotoclax + Zanubrutinib Sonrotoclax Zanubrutinib 0 10


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