Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name SIAIS562055
Trade Name
Synonyms SIAIS-562055|SIAIS 562055
Drug Descriptions

SIAIS562055 is a proteolysis targeting chimera (PROTAC) targeting SOS1, which potentially decreases downstream Erk signaling, tumor cell proliferation, and tumor growth (PMID: 39437162).

DrugClasses SOS1 Inhibitor 16
CAS Registry Number NA
NCIT ID NA

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + SIAIS562055 Adagrasib SIAIS562055 0 0
Imatinib + SIAIS562055 Imatinib SIAIS562055 0 0
MRTX-1133 + SIAIS562055 MRTX-1133 SIAIS562055 0 0
Nilotinib + SIAIS562055 Nilotinib SIAIS562055 0 0
Olverembatinib + SIAIS562055 Olverembatinib SIAIS562055 0 0
SIAIS562055 SIAIS562055 0 0
SIAIS562055 + Sotorasib SIAIS562055 Sotorasib 0 0


Additional content available in CKB BOOST