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Drug Name Olverembatinib
Trade Name
Synonyms HQP 1351|HQP-1351|GZD824 dimesylate|GZD824|HQP1351
Drug Descriptions

Olverembatinib (HQP1351) is a third-generation BCR-ABL inhibitor and multikinase inhibitor that inhibits KIT, ABL1, FGFR1, FLT3, and PDGFRA (PMID: 32247263), which potentially induces apoptosis, and inhibits tumor cell growth, migration, and invasion (PMID: 31673329).

DrugClasses ABL1 Inhibitor 8 FGFR1 Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57 PDGFR-alpha Inhibitor 9
CAS Registry Number 1421783-64-3
NCIT ID C165549

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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-2575 + Decitabine + Olverembatinib APG-2575 Decitabine Olverembatinib 0 1
APG-2575 + Olverembatinib APG-2575 Olverembatinib 1 0
BGT226 + Olverembatinib BGT226 Olverembatinib 0 0
Bosutinib + Olverembatinib Bosutinib Olverembatinib 0 1
GSK690693 + Olverembatinib GSK690693 Olverembatinib 0 0
Inotuzumab ozogamicin + Olverembatinib Inotuzumab ozogamicin Olverembatinib 0 0
Olverembatinib Olverembatinib 26 2
Olverembatinib + SIAIS562055 Olverembatinib SIAIS562055 0 0
Olverembatinib + Torin 2 Olverembatinib Torin 2 0 0
Olverembatinib + ZSTK474 Olverembatinib ZSTK474 0 0


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