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Drug Name | HQP1351 |
Trade Name | |
Synonyms | HQP 1351|HQP-1351|GZD824 dimesylate|GZD824|Olverembatinib |
Drug Descriptions |
GZD824 (HQP1351) is a third-generation BCR-ABL inhibitor and multikinase inhibitor that inhibits KIT, ABL1, FGFR1, FLT3, and PDGFRA (PMID: 32247263), which potentially induces apoptosis, and inhibits tumor cell growth, migration, and invasion (PMID: 31673329). |
DrugClasses | ABL1 Inhibitor 8 FGFR1 Inhibitor 28 FLT3 Inhibitor 69 KIT Inhibitor 57 PDGFR-alpha Inhibitor 9 |
CAS Registry Number | 1421783-64-3 |
NCIT ID | C165549 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
APG-2575 + Decitabine + HQP1351 | APG-2575 Decitabine HQP1351 | 0 | 1 |
APG-2575 + HQP1351 | APG-2575 HQP1351 | 1 | 0 |
BGT226 + HQP1351 | BGT226 HQP1351 | 0 | 0 |
Bosutinib + HQP1351 | Bosutinib HQP1351 | 0 | 1 |
GSK690693 + HQP1351 | GSK690693 HQP1351 | 0 | 0 |
HQP1351 | HQP1351 | 26 | 2 |
HQP1351 + Inotuzumab ozogamicin | HQP1351 Inotuzumab ozogamicin | 0 | 0 |
HQP1351 + Torin 2 | HQP1351 Torin 2 | 0 | 0 |
HQP1351 + ZSTK474 | HQP1351 ZSTK474 | 0 | 0 |