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Drug Name Cediranib
Trade Name
Synonyms AZD-2171|Recentin|AZD2171|AZD 2171
Drug Descriptions

Cediranib (AZD-2171) is an ATP-competitive inhibitor of all three vascular endothelial growth factor receptors (FLT1, KDR, and FLT4) and KIT, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth (PMID: 15899831, PMID: 24714778, PMID: 32444417).

DrugClasses KIT Inhibitor 57 VEGFR1 Inhibitor 6 VEGFR2 Inhibitor 37 VEGFR3 Inhibitor 6
CAS Registry Number 288383-20-0
NCIT ID C80867

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Cediranib Bevacizumab Cediranib 0 0
Carboplatin + Cediranib Carboplatin Cediranib 0 0
Carboplatin + Cediranib + Paclitaxel Carboplatin Cediranib Paclitaxel 0 0
Cediranib Cediranib 14 5
Cediranib + Cisplatin + Gemcitabine Cediranib Cisplatin Gemcitabine 0 0
Cediranib + Cisplatin + Pemetrexed Disodium Cediranib Cisplatin Pemetrexed Disodium 0 1
Cediranib + Durvalumab Cediranib Durvalumab 0 4
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 0 1
Cediranib + Gefitinib Cediranib Gefitinib 0 0
Cediranib + Lenalidomide Cediranib Lenalidomide 0 1
Cediranib + Lomustine Cediranib Lomustine 0 0
Cediranib + Olaparib Cediranib Olaparib 2 16
Cediranib + Olaparib + Triapine Cediranib Olaparib Triapine 0 0
Cediranib + PLX4720 Cediranib PLX4720 1 0
Cediranib + PLX4720 + Selumetinib Cediranib PLX4720 Selumetinib 1 0
Cediranib + Saracatinib Cediranib Saracatinib 1 0
Cediranib + Triapine Cediranib Triapine 0 0


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