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Drug Name Valproic acid
Trade Name Stavzor
Synonyms Depacon|Valproate Sodium|Depakene
Drug Descriptions

Valproic acid inhibits HDAC activity, potentially resulting in decreased angiogenesis, increased tumor cell differentiation, and reduced tumor growth (PMID: 11742974, PMID: 14978230). Valproic acid is FDA-approved for use in treating seizures (FDA.gov).

DrugClasses HDAC Inhibitor 45
CAS Registry Number 99-66-1
NCIT ID C29536

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Valproic acid Avelumab Valproic acid 0 1
Bevacizumab + Capecitabine + Oxaliplatin + Valproic acid Bevacizumab Capecitabine Oxaliplatin Valproic acid 0 1
Bevacizumab + Capecitabine + Valproic acid Bevacizumab Capecitabine Valproic acid 0 1
Bevacizumab + Cetuximab + Temsirolimus + Valproic acid Bevacizumab Cetuximab Temsirolimus Valproic acid 0 0
Bevacizumab + Docetaxel + Gemcitabine + Valproic acid Bevacizumab Docetaxel Gemcitabine Valproic acid 0 1
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Valproic acid Bevacizumab Fluorouracil Leucovorin Oxaliplatin Valproic acid 0 1
Bevacizumab + Fluorouracil + Valproic acid Bevacizumab Fluorouracil Valproic acid 0 1
Bevacizumab + Temsirolimus + Valproic acid Bevacizumab Temsirolimus Valproic acid 0 1
Capecitabine + Cisplatin + Gemcitabine + Nab-paclitaxel + Simvastatin + Valproic acid Capecitabine Cisplatin Gemcitabine Nab-paclitaxel Simvastatin Valproic acid 0 1
Capecitabine + Radiotherapy + Valproic acid Capecitabine Radiotherapy Valproic acid 0 1
Cetuximab + Panitumumab + Valproic acid Cetuximab Panitumumab Valproic acid 0 1
Ellipticine + Valproic acid Ellipticine Valproic acid 0 0
Epirubicin + Valproic acid Epirubicin Valproic acid 0 0
Fotemustine + Valproic acid Fotemustine Valproic acid 0 0
Gemcitabine + Nab-paclitaxel + Simvastatin + Valproic acid Gemcitabine Nab-paclitaxel Simvastatin Valproic acid 0 1
Mitomycin C + Valproic acid Mitomycin C Valproic acid 0 0
Nivolumab + Valproic acid Nivolumab Valproic acid 0 1
Olaparib + Valproic acid Olaparib Valproic acid 1 0
Radiotherapy + Valproic acid Radiotherapy Valproic acid 0 1
Temozolomide + Valproic acid Temozolomide Valproic acid 0 0
Trametinib + Valproic acid Trametinib Valproic acid 1 0
Valproic acid Valproic acid 1 10


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