Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | APR-246 |
Trade Name | |
Synonyms | p53 activator APR-246|PRIMA-1MET|PRIMA-1 analogue APR-246|Eprenetapopt |
Drug Descriptions |
APR-246 is an analogue of PRIMA-1, which modifies the core domain of mutant p53, resulting in restoration of wild-type p53 conformation and reactivation of normal p53 function, leading to increased cell cycle arrest and tumor cell death (PMID: 20498645, PMID: 29670092). |
DrugClasses | p53 Activator 12 |
CAS Registry Number | 5291-32-7 |
NCIT ID | C85465 |