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Drug Name | APR-246 |
Trade Name | |
Synonyms | p53 activator APR-246|PRIMA-1MET|PRIMA-1 analogue APR-246|Eprenetapopt |
Drug Descriptions |
APR-246 is an analogue of PRIMA-1, which modifies the core domain of mutant p53, resulting in restoration of wild-type p53 conformation and reactivation of normal p53 function, leading to increased cell cycle arrest and tumor cell death (PMID: 20498645, PMID: 29670092). |
DrugClasses | p53 Activator 11 |
CAS Registry Number | 5291-32-7 |
NCIT ID | C85465 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Acalabrutinib + APR-246 | APR-246 Acalabrutinib | 0 | 1 |
APR-246 | APR-246 | 5 | 0 |
APR-246 + Azacitidine | APR-246 Azacitidine | 0 | 3 |
APR-246 + Azacitidine + Venetoclax | APR-246 Azacitidine Venetoclax | 0 | 1 |
APR-246 + Carboplatin | APR-246 Carboplatin | 0 | 0 |
APR-246 + Carboplatin + Doxorubicin | APR-246 Carboplatin Doxorubicin | 0 | 1 |
APR-246 + Cisplatin | APR-246 Cisplatin | 11 | 0 |
APR-246 + Ibrutinib | APR-246 Ibrutinib | 0 | 0 |
APR-246 + Ibrutinib + Rituximab + Venetoclax | APR-246 Ibrutinib Rituximab Venetoclax | 0 | 0 |
APR-246 + Pembrolizumab | APR-246 Pembrolizumab | 0 | 1 |
APR-246 + Radiotherapy | APR-246 Radiotherapy | 0 | 0 |
APR-246 + Rituximab + Venetoclax | APR-246 Rituximab Venetoclax | 0 | 1 |
APR-246 + Venetoclax | APR-246 Venetoclax | 0 | 1 |