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Drug Name | Idasanutlin |
Trade Name | |
Synonyms | RO-5503781|RO 5503781|RO5503781|RG7388|RG-7388 |
Drug Descriptions |
Idasanutlin (RG7388) binds to MDM2 to block subsequent interaction with p53, which prevents degradation of p53, thereby resulting in restoration of wild-type p53 activity and potentially promoting apoptosis of tumor cells (PMID: 23808545, PMID: 32338053, PMID: 32020437). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 1229705-06-9 |
NCIT ID | C99131 |