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Drug Name | Birabresib |
Trade Name | |
Synonyms | Y-803|MK-8628|OTX015|OTX-015 |
Drug Descriptions |
Birabresib (OTX015) is an inhibitor of the BET bromodomain proteins BRD3, BRD4, and BRD5, which inhibits interaction with acetylated histone H4, potentially resulting in decreased tumor cell proliferation (Mol Cancer Ther Nov 2013 12:C244, PMID: 29733771, PMID: 31204545). |
DrugClasses | BET Inhibitor (Pan) 32 |
CAS Registry Number | 202590-98-5 |
NCIT ID | C103298 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BC2059 + Birabresib | BC2059 Birabresib | 0 | 0 |
BC2059 + Birabresib + Venetoclax | BC2059 Birabresib Venetoclax | 0 | 0 |
Birabresib | Birabresib | 3 | 3 |
Birabresib + Bortezomib | Birabresib Bortezomib | 0 | 0 |
Birabresib + Carfilzomib | Birabresib Carfilzomib | 0 | 0 |
Birabresib + Crizotinib | Birabresib Crizotinib | 0 | 0 |
Birabresib + FHD-286 | Birabresib FHD-286 | 1 | 0 |
Birabresib + GSK2801 | Birabresib GSK2801 | 0 | 0 |
Birabresib + Osimertinib | Birabresib Osimertinib | 0 | 0 |
Birabresib + Rucaparib | Birabresib Rucaparib | 0 | 0 |
Birabresib + Venetoclax | Birabresib Venetoclax | 0 | 0 |
Birabresib + Ziftomenib | Birabresib Ziftomenib | 0 | 0 |