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Drug Name | Asciminib |
Trade Name | Scemblix |
Synonyms | ABL001|ABL-001 |
Drug Descriptions |
Scemblix (asciminib) is an allosteric inhibitor of BCR-ABL that binds to a unique location outside the ATP binding site, resulting in decreased BCR-ABL kinase activity and reduced tumor growth (PMID: 31543464, PMID: 31826340). Scemblix (asciminib) is FDA approved for use in patients with newly-diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), and in Ph+ CML patients in CP after two or more tyrosine kinase inhibitor treatments, and in adult patients with Ph+ CML in CP harboring ABL1 T315I (FDA.gov). |
DrugClasses | BCR-ABL Inhibitor 32 |
CAS Registry Number | 1492952-76-7 |
NCIT ID | C114494 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Asciminib | Asciminib | 1 | 13 |
Asciminib + Blinatumomab | Asciminib Blinatumomab | 0 | 1 |
Asciminib + Blinatumomab + Dasatinib + Prednisone | Asciminib Blinatumomab Dasatinib Prednisone | 0 | 1 |
Asciminib + Dasatinib | Asciminib Dasatinib | 0 | 3 |
Asciminib + Dasatinib + Prednisone | Asciminib Dasatinib Prednisone | 0 | 0 |
Asciminib + Hydroxyurea + Ponatinib | Asciminib Hydroxyurea Ponatinib | 0 | 0 |
Asciminib + Imatinib | Asciminib Imatinib | 0 | 6 |
Asciminib + Nilotinib | Asciminib Nilotinib | 0 | 5 |
Asciminib + Ponatinib | Asciminib Ponatinib | 0 | 0 |