Asciminib
Drug Detail
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| Drug Name | Asciminib |
| Trade Name | Scemblix |
| Synonyms | ABL001|ABL-001 |
| Drug Descriptions |
Scemblix (asciminib) is an allosteric inhibitor of BCR-ABL that binds to a unique location outside the ATP binding site, resulting in decreased BCR-ABL kinase activity and reduced tumor growth (PMID: 31543464, PMID: 31826340). Scemblix (asciminib) is FDA approved for use in patients with newly-diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), and in Ph+ CML patients in CP after two or more tyrosine kinase inhibitor treatments, and in adult patients with Ph+ CML in CP harboring ABL1 T315I (FDA.gov). |
| DrugClasses | BCR-ABL Inhibitor 32 |
| CAS Registry Number | 1492952-76-7 |
| NCIT ID | C114494 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Asciminib | Asciminib | 1 | 19 |
| Asciminib + Blinatumomab | Asciminib Blinatumomab | 0 | 1 |
| Asciminib + Blinatumomab + Dasatinib + Prednisone | Asciminib Blinatumomab Dasatinib Prednisone | 0 | 1 |
| Asciminib + Dasatinib | Asciminib Dasatinib | 0 | 4 |
| Asciminib + Dasatinib + Prednisone | Asciminib Dasatinib Prednisone | 0 | 0 |
| Asciminib + Hydroxyurea + Ponatinib | Asciminib Hydroxyurea Ponatinib | 0 | 0 |
| Asciminib + Imatinib | Asciminib Imatinib | 0 | 6 |
| Asciminib + Nilotinib | Asciminib Nilotinib | 0 | 7 |
| Asciminib + Ponatinib | Asciminib Ponatinib | 0 | 0 |
| Asciminib + Sildenafil | Asciminib Sildenafil | 0 | 1 |
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