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Drug Name Blinatumomab
Trade Name Blincyto
Synonyms anti-CD19/anti-CD3 recombinant bispecific|monoclonal antibody MT103|MEDI-538
Drug Descriptions

Blincyto (blinatumomab) is a bispecific antibody that binds both CD19 on B-cells and the CD3 complex on T-cells, therefore facilitates T-cell mediated killing of CD19-expressing tumor cells (PMID: 26337639). Blincyto (blinatumomab) is FDA-approved for use in adult and pediatric patients one month and older with relapsed or refractory CD19-positive B-cell precursor acute lymphoblastic leukemia (ALL), CD19-positive B-cell precursor ALL in remission, and CD19-positive, BCR-ABL1-negative B-cell precursor ALL in the consolidation phase (FDA.gov).

DrugClasses CD19 Antibody 21
CAS Registry Number 853426-35-4
NCIT ID C62528

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 404 + Blinatumomab AMG 404 Blinatumomab 0 1
Asciminib + Blinatumomab Asciminib Blinatumomab 0 1
Asciminib + Blinatumomab + Dasatinib + Prednisone Asciminib Blinatumomab Dasatinib Prednisone 0 1
Blinatumomab Blinatumomab 1 21
Blinatumomab + Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Dexamethasone + Hydrocortisone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Vincristine Sulfate Blinatumomab Calaspargase pegol-mknl Cyclophosphamide Cytarabine Dasatinib Daunorubicin Dexamethasone Hydrocortisone Inotuzumab ozogamicin Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Blinatumomab + CF33-CD19t Blinatumomab CF33-CD19t 0 1
Blinatumomab + Cyclophosphamide + Cytarabine + Dexamethasone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Blinatumomab Cyclophosphamide Cytarabine Dexamethasone Inotuzumab ozogamicin Mercaptopurine Methotrexate Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Cytarabine + Dexamethasone + Methotrexate + Pegaspargase + Vincristine Sulfate Blinatumomab Cyclophosphamide Cytarabine Dexamethasone Methotrexate Pegaspargase Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Dexamethasone + Doxorubicin + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Doxorubicin Inotuzumab ozogamicin Vincristine Sulfate 0 0
Blinatumomab + Cyclophosphamide + Dexamethasone + Doxorubicin + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Doxorubicin Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Dexamethasone + Doxorubicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Doxorubicin Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 1
Blinatumomab + Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Blinatumomab Cytarabine Dasatinib Dexamethasone Hydrocortisone Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Blinatumomab + Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Blinatumomab Cytarabine Dasatinib Dexamethasone Hydrocortisone Methotrexate Venetoclax 0 1
Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax Blinatumomab Cytarabine Dexamethasone Hydrocortisone Methotrexate Venetoclax 0 1
Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone Sodium Succinate + Leucovorin + Methotrexate + Nivolumab Blinatumomab Cytarabine Dexamethasone Hydrocortisone Sodium Succinate Leucovorin Methotrexate Nivolumab 0 1
Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone Sodium Succinate + Methotrexate Blinatumomab Cytarabine Dexamethasone Hydrocortisone Sodium Succinate Methotrexate 0 1
Blinatumomab + Cytarabine + Dexamethasone + Hydrocortisone Sodium Succinate + Methotrexate + Nivolumab Blinatumomab Cytarabine Dexamethasone Hydrocortisone Sodium Succinate Methotrexate Nivolumab 0 1
Blinatumomab + Cytarabine + Dexamethasone + Leucovorin + Methotrexate + Nivolumab Blinatumomab Cytarabine Dexamethasone Leucovorin Methotrexate Nivolumab 0 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate Blinatumomab Cytarabine Dexamethasone Methotrexate 0 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Nivolumab Blinatumomab Cytarabine Dexamethasone Methotrexate Nivolumab 0 0
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 0
Blinatumomab + Cytarabine + Methotrexate + Ponatinib Blinatumomab Cytarabine Methotrexate Ponatinib 0 1
Blinatumomab + Dasatinib Blinatumomab Dasatinib 0 1
Blinatumomab + Dasatinib + Dexamethasone Blinatumomab Dasatinib Dexamethasone 0 0
Blinatumomab + Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Dasatinib Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 0
Blinatumomab + Dasatinib + Dexamethasone + Methotrexate Blinatumomab Dasatinib Dexamethasone Methotrexate 0 0
Blinatumomab + Dasatinib + Dexamethasone + Methotrexate + Prednisone Blinatumomab Dasatinib Dexamethasone Methotrexate Prednisone 0 1
Blinatumomab + Dasatinib + Dexamethasone + Prednisone Blinatumomab Dasatinib Dexamethasone Prednisone 0 1
Blinatumomab + Dasatinib + Methotrexate Blinatumomab Dasatinib Methotrexate 0 1
Blinatumomab + Dexamethasone Blinatumomab Dexamethasone 0 1
Blinatumomab + Dexamethasone + Leucovorin Blinatumomab Dexamethasone Leucovorin 0 1
Blinatumomab + Dexamethasone + Leucovorin + Methotrexate Blinatumomab Dexamethasone Leucovorin Methotrexate 0 1
Blinatumomab + Dexamethasone + Methotrexate Blinatumomab Dexamethasone Methotrexate 0 2
Blinatumomab + Dexamethasone + Methotrexate + Nivolumab Blinatumomab Dexamethasone Methotrexate Nivolumab 0 1
Blinatumomab + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Dexamethasone Methotrexate Ponatinib 0 0
Blinatumomab + Dexamethasone + Methotrexate + Ponatinib + Prednisone Blinatumomab Dexamethasone Methotrexate Ponatinib Prednisone 0 1
Blinatumomab + Dexamethasone + Ponatinib Blinatumomab Dexamethasone Ponatinib 0 0
Blinatumomab + Dexamethasone + Ponatinib + Prednisone Blinatumomab Dexamethasone Ponatinib Prednisone 0 1
Blinatumomab + Ibrutinib Blinatumomab Ibrutinib 0 1
Blinatumomab + Imatinib Blinatumomab Imatinib 0 1
Blinatumomab + Inotuzumab ozogamicin Blinatumomab Inotuzumab ozogamicin 0 2
Blinatumomab + Ipilimumab + Nivolumab Blinatumomab Ipilimumab Nivolumab 0 1
Blinatumomab + Leucovorin + Methotrexate Blinatumomab Leucovorin Methotrexate 0 1
Blinatumomab + Mercaptopurine + Methotrexate Blinatumomab Mercaptopurine Methotrexate 0 1
Blinatumomab + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Blinatumomab Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Blinatumomab + Methotrexate Blinatumomab Methotrexate 0 2
Blinatumomab + Methotrexate + Nivolumab Blinatumomab Methotrexate Nivolumab 0 1
Blinatumomab + Pembrolizumab Blinatumomab Pembrolizumab 0 4
Blinatumomab + Ponatinib Blinatumomab Ponatinib 0 2
Blinatumomab + Venetoclax Blinatumomab Venetoclax 0 1


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