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Drug Name | BI-3406 |
Trade Name | |
Synonyms | HY-125817|EX-A3418|BI3406|BI 3406 |
Drug Descriptions |
BI-3406 binds to SOS1 thus prevents SOS1 interaction with Kras-GDP, resulting in inhibition of Kras downstream signaling and potential inhibition of tumor cell growth (AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Oct 2019, Abstract PL06-01, PMID: 32816843). |
DrugClasses | SOS1 Inhibitor 16 |
CAS Registry Number | 2230836-55-0 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib + BI-3406 | Adagrasib BI-3406 | 0 | 0 |
BI-3406 | BI-3406 | 5 | 0 |
BI-3406 + Binimetinib + Radiotherapy | BI-3406 Binimetinib Radiotherapy | 0 | 0 |
BI-3406 + MRTX-1133 | BI-3406 MRTX-1133 | 0 | 0 |
BI-3406 + RO5126766 | BI-3406 RO5126766 | 0 | 0 |
BI-3406 + Selumetinib | BI-3406 Selumetinib | 0 | 0 |
BI-3406 + Sotorasib | BI-3406 Sotorasib | 0 | 0 |
BI-3406 + TNO155 | BI-3406 TNO155 | 0 | 0 |
BI-3406 + Trametinib | BI-3406 Trametinib | 0 | 0 |