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| Gene | SMARCA4 |
| Variant | E952fs |
| Impact List | frameshift |
| Protein Effect | loss of function - predicted |
| Gene Variant Descriptions | SMARCA4 E952fs results in a change in the amino acid sequence of the Smarca4 protein beginning at aa 952 of 1647, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the Bromo domain (UniProt.org), E952fs is predicted to lead to a loss of Smarca4 protein function. |
| Associated Drug Resistance | |
| Category Variants Paths |
SMARCA4 mutant SMARCA4 inact mut SMARCA4 E952fs |
| Transcript | NM_003072.5 |
| gDNA | chr19:g.(11021961_11021962) |
| cDNA | c.(2854_2853) |
| Protein | p.E952fs |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| XM_011528198 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128849.3 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439246.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128846.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128848.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_006722845.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_006722846.3 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_003072.5 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_003072 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027164 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128846 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451663.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451662.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001374457.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128844.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439244.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439243.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128845.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_011528198.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027167 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128847.4 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451666.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451658.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451658.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451660.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027166 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451667.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451659.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451665.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128844.3 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027163 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451661.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001411150.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027165 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027160 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451663.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_006722845 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_011528198.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451667.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439250.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128845.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128848.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_003072.3 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027168 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451664.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_024451661.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128845 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439249.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027162 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439248.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128847.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128846.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128844 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128849.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_006722846.2 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439247.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001387283.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_006722846 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_047439251.1 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128849 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128848 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| XM_017027161 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| NM_001128847 | chr19:g.(11021961_11021962) | c.(2854_2853) | p.E952fs | RefSeq | GRCh38/hg38 |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 inact mut | melanoma | not predictive | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, somatic loss-of-function mutations in the genes of the mSWI/SNF complex, including SMARCA4, did not correlate with improved survival in 2 separate cohorts of patients with melanoma treated with systemic immune checkpoint inhibitors, with adjusted HRs for overall survival of 1.70 (p=0.192, n=86) and 1.02 (p=0.939, n=192), respectively (PMID: 32321774). | 32321774 |
| SMARCA4 inact mut | gastroesophageal adenocarcinoma | not predictive | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, somatic loss-of-function mutations in the genes of the mSWI/SNF complex, including SMARCA4, did not correlate with improved survival in 2 separate cohorts of patients with gastroesophageal adenocarcinoma treated with systemic immune checkpoint inhibitors, with adjusted HRs for overall survival of 0.70 (p=0.403, n=66) and 0.46 (p=0.071, n=59), respectively (PMID: 32321774). | 32321774 |
| SMARCA4 inact mut | colorectal adenocarcinoma | unknown | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, somatic loss-of-function mutations in the genes of the mSWI/SNF complex, including SMARCA4, correlated with improved survival in one cohort of patients with colorectal adenocarcinoma treated with systemic immune checkpoint inhibitors but not the other, with adjusted HRs for overall survival of 0.30 (p=0.03, n=35) and 0.56 (p=0.244, n=63), respectively (PMID: 32321774). | 32321774 |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | Alisertib | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring an inactivating mutation in SMARCA4 demonstrated sensitivity to Alisertib (MLN8237) in culture (PMID: 28102363). | 28102363 |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | Danusertib | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring an inactivating mutation in SMARCA4 demonstrated sensitivity to Danusertib (PHA-739358) in culture (PMID: 28102363). | 28102363 |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | MK-5108 | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring an inactivating mutation in SMARCA4 demonstrated sensitivity to MK-5108 (VX-689) in culture (PMID: 28102363). | 28102363 |
| SMARCA4 inact mut | transitional cell carcinoma | not predictive | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, somatic loss-of-function mutations in the genes of the mSWI/SNF complex, including SMARCA4, did not correlate with improved survival in 2 separate cohorts of patients with transitional cell carcinoma treated with systemic immune checkpoint inhibitors, with adjusted HRs for overall survival of 1.44 (p=0.34, n=56) and 0.82 (p=0.559, n=93), respectively (PMID: 32321774). | 32321774 |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | ENMD-2076 | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring an inactivating mutation in SMARCA4 demonstrated sensitivity to ENMD-2076 in culture (PMID: 28102363). | 28102363 |
| SMARCA4 inact mut | head and neck squamous cell carcinoma | not predictive | unspecified immune checkpoint inhibitor | Clinical Study - Cohort | Actionable | In a retrospective analysis, somatic loss-of-function mutations in the genes of the mSWI/SNF complex, including SMARCA4, did not correlate with improved survival in 2 separate cohorts of patients with head and neck squamous cell carcinoma treated with systemic immune checkpoint inhibitors, with adjusted HRs for overall survival of 0.74 (p=0.631, n=31) and 0.76 (p=0.622, n=68), respectively (PMID: 32321774). | 32321774 |
| SMARCA4 inact mut | Advanced Solid Tumor | no benefit | Palbociclib | Clinical Study | Actionable | In a combined analysis of 2 clinical trials (DRUP, MoST), Ibrance (palbociclib) or Kisqali (ribociclib) monotherapy had limited efficacy and resulted in no objective responses, a 15% clinical benefit rate at 16 weeks, median progression-free survival of 4 mo, and median overall survival of 5 mo in previously treated advanced solid tumor patients (n=112) with inactivating SMARCA4 mutations, CDKN2A loss, or CDK4, CDK6, CCND1, CCND2, or CCND3 amplification (PMID: 37424386; NCT02925234, ACTRN12616000931471). | 37424386 |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | Tozasertib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, non-small cell lung cancer cell lines harboring SMARCA4 inactivating mutations demonstrated sensitivity to Tozasertib (VX-680) in culture and in xenograft models (PMID: 28102363). | 28102363 |
| SMARCA4 mutant | mantle cell lymphoma | predicted - resistant | Ibrutinib + Venetoclax | Phase II | Actionable | In a Phase II trial (AIM), distinct molecular profiles were identified in mantle cell lymphoma patients responded to Imbruvica (ibrutinib) and Venclexta (venetoclax) combination therapy compared to those did not respond, with all patients harboring mutations in NSD2 (n=4), UBR5 (n=3), KMT2D (n=3), and 12 of 13 patients harboring mutations in ATM responded to the therapy, while SMARCA4 (n=4), CCND1 (n=2), and NOTCH1 (n=3) alterations were exclusively observed in nonresponders (PMID: 30455436; NCT02471391). | 30455436 |
| SMARCA4 mutant | lung non-small cell carcinoma | predicted - sensitive | PRT3789 | Phase I | Actionable | In a Phase I trial, PRT3789 treatment was well tolerated and resulted in partial responses, tumor shrinkage, and prolonged stable disease in patients with advanced esophageal cancer (N=2) or non-small cell lung cancer (N=18) harboring SMARCA4 mutations (Ann Oncol (2024) 35 (suppl_2): S483-S484; NCT05639751). | detail... |
| SMARCA4 mutant | esophageal cancer | predicted - sensitive | PRT3789 | Case Reports/Case Series | Actionable | In a Phase I trial, PRT3789 treatment was well tolerated and resulted in partial responses, tumor shrinkage, and prolonged stable disease in patients with advanced esophageal cancer (N=2) or non-small cell lung cancer (N=18) harboring SMARCA4 mutations (Ann Oncol (2024) 35 (suppl_2): S483-S484; NCT05639751). | detail... |
| SMARCA4 mutant | small-cell carcinoma of the ovary of hypercalcemic type | sensitive | Ponatinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Iclusig (ponatinib) treatment of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) cell lines and xenografts with mutant SMARCA4 resulted in decreased cell viability and tumor volume (PMID: 29440177). | 29440177 |
| SMARCA4 mutant | lung non-small cell carcinoma | predicted - sensitive | Tozasertib | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring a SMARCA4 mutation demonstrated sensitivity to Tozasertib (VX-680) in culture (Cancer Res July 15 2016 (76) (14 Supplement) LB-318). | detail... |