Molecular Profile Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03822117	Phase II	Pemigatinib	Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)	Terminated	USA \| ITA \| ISR \| GBR \| FRA \| ESP \| DNK \| DEU \| CHE	2
NCT01976741	Phase I	Rogaratinib	Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor	Completed	USA \| FRA \| ESP \| DEU \| CHE	2
NCT05614739	Phase I	LOXO-435 + Pembrolizumab LOXO-435	A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3	Recruiting	USA \| NOR \| NLD \| ITA \| ISR \| GBR \| FRA \| ESP \| DEU \| CAN \| AUS	3
NCT04923126	Phase Ib/II	Mirdametinib	SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma	Recruiting	USA	0
NCT06319820	Phase III	Mitomycin C Gemcitabine Erdafitinib	A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer (MoonRISe-1)	Recruiting	USA \| TUR \| POL \| ITA \| ISR \| IRL \| GBR \| FRA \| ESP \| DNK \| DEU \| CZE \| BRA \| BEL \| AUT \| ARG	4
NCT05244551	Phase I	ABSK061	A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK061 in Patients With Advanced Solid Tumors	Recruiting	USA	1
NCT02925234	Phase II	Niraparib Tepotinib Erdafitinib Ivosidenib Panitumumab Pemigatinib	The Drug Rediscovery Protocol (DRUP Trial) (DRUP)	Recruiting	NLD	0
NCT03390504	Phase III	Pembrolizumab Erdafitinib Docetaxel + Vinflunine	A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations (THOR)	Active, not recruiting	USA \| TUR \| POL \| NLD \| ITA \| ISR \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CAN \| BRA \| BGR \| BEL \| AUT \| AUS \| ARG	8
NCT04096417	Phase II	Pemigatinib	Pemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations	Unknown status	USA	0
NCT06302621	Phase I	Afatinib + Pemigatinib	Pemigatinib + Afatinib in Advanced Refractory Solid Tumors	Recruiting	USA	0
NCT03732703	Phase Ib/II	Dexamethasone + Enasidenib + Ixazomib + Pomalidomide Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Dexamethasone + Erdafitinib + Ixazomib + Pomalidomide Dexamethasone + Ixazomib + Pomalidomide + Venetoclax Abemaciclib + Dexamethasone + Ixazomib + Pomalidomide Daratumumab + Dexamethasone + Ixazomib + Pomalidomide	Myeloma-Developing Regimens Using Genomics (MyDRUG) (MyDRUG)	Completed	USA	0
NCT05253807	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration (FIGHT-210)	Completed	USA \| ITA \| FRA \| ESP \| DEU	0
NCT03767075	Phase II	Amivantamab-vmjw Futibatinib Atezolizumab	A Modular Multi-Basket Trial to Improve Personalized Medicine in Cancer Patients (Basket of Baskets) (BoB)	Recruiting	SWE \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU	0
NCT06906562	Phase II	Pemigatinib	A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations	Recruiting	USA	0
NCT05544552	Phase Ib/II	TYRA-300	Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations (SURF301)	Recruiting	USA \| FRA \| ESP \| AUS	0
NCT05176665	Phase Ib/II	EMB-01	EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers	Recruiting	USA	1
NCT05804227	Phase I	Ulixertinib	Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas	Recruiting	USA	0
NCT01975701	Phase II	Infigratinib	A Phase 2 Study of BGJ398 in Patients With Recurrent GBM	Completed	USA \| NLD \| ESP \| CHE \| BEL \| AUS	0
NCT04197986	Phase III	Infigratinib	Study of Oral Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations	Terminated	USA \| NLD \| ITA \| GRC \| GBR \| FRA \| ESP \| DEU \| CAN \| BGR \| BEL	0
NCT05316155	Phase I	Erdafitinib	Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer	Recruiting	USA \| NLD \| ISR \| ESP \| DEU \| CAN	2
NCT06995677	Phase II	TYRA-300	Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer (SURF302)	Recruiting	USA	0
NCT02657486	Phase 0	Infigratinib	BGJ398 in Non-Muscle-Invasive Urothelial Carcinoma of the Bladder	Active, not recruiting	USA	0
NCT05267106	Phase II	Pemigatinib	Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations (FIGHT-209)	Terminated	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DNK \| DEU	1
NCT02052778	Phase Ib/II	Futibatinib	A Study of TAS-120 in Patients With Advanced Solid Tumors	Completed	USA \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CAN \| AUS	4
NCT04917809	Phase II	Erdafitinib	A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer	Active, not recruiting	USA	0
NCT02272998	Phase II	Ponatinib	Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.	Completed	USA	0
NCT04963153	Phase I	Enfortumab vedotin-ejfv + Erdafitinib	Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy	Active, not recruiting	USA \| CAN	0
NCT03827850	Phase II	Erdafitinib	FGFR Inhibitor in FGFR Dysregulated Cancer (FIND)	Terminated	DEU	0
NCT06915753	Phase I	TYRA-430	Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations (SURF431)	Recruiting	USA \| CAN	2
NCT06874335	Phase I	BHV-1530	A Phase 1 Study of BHV-1530 (AMB302) in Advanced Solid Tumors	Recruiting	USA	0
NCT05627063	Phase I	ABSK121	A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK121-NX in Patients With Advanced Solid Tumors	Active, not recruiting	USA	1

Profile Name	FGFR3 act mut
Gene Variant Detail	FGFR3 act mut (gain of function)
Relevant Treatment Approaches	FGFR Inhibitor (Pan) FGFR3 Inhibitor

Molecular Profile Detail

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