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Therapy Name Iberdomide + ISB 2001
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ISB 2001 ISB2001|ISB-2001|ABBV-2001|ABBV2001|ABBV 2001 CD3 Antibody 128 CD38 Antibody 21 TNFRSF17 Antibody 22 ISB 2001 is a trispecific T-cell engager targeting CD3 on T cells and BCMA and CD38 on tumor cells, which potentially decreases tumor growth (Blood (2022) 140 (Supplement 1): 858-859).
Iberdomide CC220|CC-220|CC 220 Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06892522 Phase Ib/II Daratumumab + Dexamethasone + Lenalidomide Etentamig + Lenalidomide CC-92480 + ISB 2001 Carfilzomib + Daratumumab + Dexamethasone Carfilzomib + Daratumumab + Dexamethasone + Etentamig Iberdomide + ISB 2001 Carfilzomib + Dexamethasone + Etentamig Etentamig Lenalidomide Daratumumab + Etentamig + Lenalidomide A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations Recruiting USA | NOR | ISR | GBR | AUS 1


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