Therapy Detail
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| Therapy Name | Iberdomide + Isatuximab + Linvoseltamab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Iberdomide | CC220|CC-220|CC 220 | Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682). | ||
| Isatuximab | Sarclisa | SAR650984|isatuximab-irfc | CD38 Antibody 21 | Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies, in combination with Kyprolis (carfilzomib) and dexamethasone for patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy, and in combination with Velcade (bortezomib), Revlimid (lenalidomide), and dexamethasone for patients with newly diagnosed multiple myeloma ineligible for transplant (FDA.gov). |
| Linvoseltamab | Lynozyfic | REGN5458|REGN-5458|REGN 5458|Anti-BCMA/CD3 BiTE|linvoseltamab-gcpt | CD3 Antibody 125 TNFRSF17 Antibody 22 | Lynozyfic (linvoseltamab) is a bispecific antibody that binds to TNFRSF17 (BCMA) and CD3 with potential antitumor activity (Blood (2019) 134 (Supplement_1): 3176). Lynozyfic (linvoseltamab) is FDA-approved for use in patients with previously-treated relapsed or refractory multiple myeloma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07624513 | Phase III | Iberdomide + Isatuximab + Melphalan Iberdomide + Isatuximab + Linvoseltamab Bortezomib + Iberdomide + Isatuximab Iberdomide Bortezomib + Dexamethasone + Iberdomide + Isatuximab Iberdomide + Isatuximab | Determination 2 - Isatuximab, Iberdomide, Bortezomib and Dexamethasone Induction, Followed by Risk- and Response-Adapted Consolidation and Maintenance Therapy, in Transplant-Eligible Patients With Newly Diagnosed Multiple Myeloma | Not yet recruiting | USA | 0 |
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