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Drug Name Calaspargase pegol-mknl
Trade Name Asparlas
Synonyms CALASP|EZN-2285EZN 2285|EZN2285|SC-PEG E. coli L-asparaginase
Drug Descriptions

Asparlas (calaspargase pegol-mknl) is a pegylated version of L-asparaginase derived from E.coli, which converts L-asparagine to ammonia and L-aspartic acid, potentially resulting in reduced levels of asparagine leading to inhibition of protein synthesis and tumor cell proliferation, and increased cell death (NCI Drug Dictionary). Asparlas (calaspargase pegol-mknl) is approved as a component of multi-agent chemotherapy in acute lymphoblastic leukemia (FDA.gov).

DrugClasses
CAS Registry Number 941577-06-6
NCIT ID C78198

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Blinatumomab + Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Dexamethasone + Hydrocortisone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Vincristine Sulfate Blinatumomab Calaspargase pegol-mknl Cyclophosphamide Cytarabine Dasatinib Daunorubicin Dexamethasone Hydrocortisone Inotuzumab ozogamicin Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Bortezomib + Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Vincristine Sulfate Bortezomib Calaspargase pegol-mknl Cyclophosphamide Cytarabine Daunorubicin Dexamethasone Hydrocortisone Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Bortezomib + Calaspargase pegol-mknl + Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Vincristine Sulfate Bortezomib Calaspargase pegol-mknl Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Vincristine Sulfate 0 1
Calaspargase pegol-mknl Calaspargase pegol-mknl 0 0
Calaspargase pegol-mknl + Cobimetinib Calaspargase pegol-mknl Cobimetinib 0 1
Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Nelarabine + Vincristine Sulfate Calaspargase pegol-mknl Cyclophosphamide Cytarabine Dasatinib Daunorubicin Dexamethasone Hydrocortisone Mercaptopurine Methotrexate Nelarabine Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Mercaptopurine + Methotrexate + Nelarabine + Venetoclax + Vincristine Sulfate Calaspargase pegol-mknl Cyclophosphamide Cytarabine Daunorubicin Dexamethasone Hydrocortisone Mercaptopurine Methotrexate Nelarabine Venetoclax Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cyclophosphamide + Dexamethasone + Doxorubicin + Rituximab + Vincristine Sulfate Calaspargase pegol-mknl Cyclophosphamide Dexamethasone Doxorubicin Rituximab Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cyclophosphamide + Dexamethasone + Doxorubicin + Vincristine Sulfate Calaspargase pegol-mknl Cyclophosphamide Dexamethasone Doxorubicin Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cyclophosphamide + Dexamethasone + Vincristine Sulfate Calaspargase pegol-mknl Cyclophosphamide Dexamethasone Vincristine Sulfate 0 0
Calaspargase pegol-mknl + Cytarabine + Dasatinib + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Vincristine Sulfate Calaspargase pegol-mknl Cytarabine Dasatinib Daunorubicin Dexamethasone Hydrocortisone Methotrexate Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cytarabine + Daunorubicin + Dexamethasone + Hydrocortisone + Methotrexate + Venetoclax + Vincristine Sulfate Calaspargase pegol-mknl Cytarabine Daunorubicin Dexamethasone Hydrocortisone Methotrexate Venetoclax Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cytarabine + Dexamethasone + Dexrazoxane + Doxorubicin + Hydrocortisone + Leucovorin + Methotrexate + Venetoclax + Vincristine Sulfate Calaspargase pegol-mknl Cytarabine Dexamethasone Dexrazoxane Doxorubicin Hydrocortisone Leucovorin Methotrexate Venetoclax Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Cytarabine + Idarubicin Calaspargase pegol-mknl Cytarabine Idarubicin 0 1
Calaspargase pegol-mknl + Decitabine + Venetoclax Calaspargase pegol-mknl Decitabine Venetoclax 0 1
Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate Calaspargase pegol-mknl Dexamethasone Etoposide Ifosfamide Methotrexate 0 1
Calaspargase pegol-mknl + Prednisolone + Vincristine Sulfate Calaspargase pegol-mknl Prednisolone Vincristine Sulfate 0 1
Calaspargase pegol-mknl + Prednisone + Vincristine Sulfate Calaspargase pegol-mknl Prednisone Vincristine Sulfate 0 1


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