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Drug Name Inotuzumab ozogamicin
Trade Name Besponsa
Synonyms CMC-544|InO
Drug Descriptions

Besponsa (inotuzumab ozogamicin) consists of calecheamicin covalently linked to anti-CD22 antibody, which delivers calecheamicin into CD22-positive cells, potentially leading to DNA damage and apoptosis (PMID: 24389139). Besponsa (inotuzumab ozogamicin) is FDA-approved for use in adult and pediatric patients 1 year and older with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (FDA.gov).

DrugClasses CD22 Immune Cell Therapy 15
CAS Registry Number 635715-01-4
NCIT ID C71542

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Fludarabine + Inotuzumab ozogamicin Bendamustine Fludarabine Inotuzumab ozogamicin 0 1
Bendamustine + Fludarabine + Inotuzumab ozogamicin + Tacrolimus Bendamustine Fludarabine Inotuzumab ozogamicin Tacrolimus 0 1
Blinatumomab + Calaspargase pegol-mknl + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Dexamethasone + Hydrocortisone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Vincristine Sulfate Blinatumomab Calaspargase pegol-mknl Cyclophosphamide Cytarabine Dasatinib Daunorubicin Dexamethasone Hydrocortisone Inotuzumab ozogamicin Mercaptopurine Methotrexate Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Cytarabine + Dexamethasone + Inotuzumab ozogamicin + Mercaptopurine + Methotrexate + Pegfilgrastim + Prednisone + Rituximab + Vincristine Sulfate Blinatumomab Cyclophosphamide Cytarabine Dexamethasone Inotuzumab ozogamicin Mercaptopurine Methotrexate Pegfilgrastim Prednisone Rituximab Vincristine Sulfate 0 1
Blinatumomab + Cyclophosphamide + Dexamethasone + Doxorubicin + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Doxorubicin Inotuzumab ozogamicin Vincristine Sulfate 0 0
Blinatumomab + Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 1
Blinatumomab + Cytarabine + Dasatinib + Dexamethasone + Hydrocortisone + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Blinatumomab Cytarabine Dasatinib Dexamethasone Hydrocortisone Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Blinatumomab + Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Blinatumomab Dasatinib Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 0
Blinatumomab + Inotuzumab ozogamicin Blinatumomab Inotuzumab ozogamicin 0 2
Bosutinib + Inotuzumab ozogamicin Bosutinib Inotuzumab ozogamicin 0 1
Cyclophosphamide + Cytarabine + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Rituximab + Vincristine Sulfate Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Mesna Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Vincristine Sulfate Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Mesna Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Vincristine Sulfate Cyclophosphamide Dexamethasone Inotuzumab ozogamicin Vincristine Sulfate 0 0
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Etoposide + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Inotuzumab ozogamicin + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Inotuzumab ozogamicin Prednisone Rituximab Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Pegaspargase Prednisone Vincristine Sulfate 0 0
Cytarabine + Daunorubicin + Inotuzumab ozogamicin + Methotrexate + Prednisone + Vincristine Sulfate Cytarabine Daunorubicin Inotuzumab ozogamicin Methotrexate Prednisone Vincristine Sulfate 0 0
Cytarabine + Inotuzumab ozogamicin + Methotrexate Cytarabine Inotuzumab ozogamicin Methotrexate 0 1
Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone Cytarabine Inotuzumab ozogamicin Methotrexate Methylprednisolone 0 1
Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone + Rituximab Cytarabine Inotuzumab ozogamicin Methotrexate Methylprednisolone Rituximab 0 1
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate 0 1
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Dasatinib + Inotuzumab ozogamicin + Methotrexate Dasatinib Inotuzumab ozogamicin Methotrexate 0 1
Daunorubicin + Inotuzumab ozogamicin + Pegaspargase + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Pegaspargase Prednisone Vincristine Sulfate 0 1
Daunorubicin + Inotuzumab ozogamicin + Prednisone + Vincristine Sulfate Daunorubicin Inotuzumab ozogamicin Prednisone Vincristine Sulfate 0 1
Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Ponatinib + Vincristine Sulfate Dexamethasone Inotuzumab ozogamicin Methotrexate Ponatinib Vincristine Sulfate 0 1
Dexamethasone + Inotuzumab ozogamicin + Venetoclax Dexamethasone Inotuzumab ozogamicin Venetoclax 0 1
Fludarabine + Inotuzumab ozogamicin + Melphalan + Tacrolimus Fludarabine Inotuzumab ozogamicin Melphalan Tacrolimus 0 1
Imatinib + Inotuzumab ozogamicin Imatinib Inotuzumab ozogamicin 0 0
Inotuzumab ozogamicin Inotuzumab ozogamicin 0 15
Inotuzumab ozogamicin + Methotrexate Inotuzumab ozogamicin Methotrexate 0 1
Inotuzumab ozogamicin + Olverembatinib Inotuzumab ozogamicin Olverembatinib 0 0
Inotuzumab ozogamicin + Ponatinib Inotuzumab ozogamicin Ponatinib 0 0
Inotuzumab ozogamicin + Venetoclax Inotuzumab ozogamicin Venetoclax 0 0
Inotuzumab ozogamicin + Vincristine sulfate liposome Inotuzumab ozogamicin Vincristine sulfate liposome 0 1


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