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Drug Name Repotrectinib
Trade Name Augtyro
Synonyms TPX-0005
Drug Descriptions

Augtyro (repotrectinib) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503, PMID: 32269053). Augtyro (repotrectinib) is FDA-approved for use in patients with advanced or metastatic ROS1 fusion-positive non-small cell lung cancer, and in adult and pediatric patients 12 years or older with advanced solid tumors harboring NTRK fusions (FDA.gov).

DrugClasses ALK Inhibitor 32 JAK2 Inhibitor 19 ROS1 Inhibitor 20 SRC Inhibitor 31 Trk Receptor Inhibitor (Pan) 32
CAS Registry Number 1802220-02-5
NCIT ID C133821

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fulvestrant + Repotrectinib Fulvestrant Repotrectinib 0 1
Gefitinib + Repotrectinib + Trametinib Gefitinib Repotrectinib Trametinib 0 0
Gilteritinib + Repotrectinib Gilteritinib Repotrectinib 0 0
Irinotecan + Repotrectinib + Temozolomide Irinotecan Repotrectinib Temozolomide 1 1
Osimertinib + Repotrectinib Osimertinib Repotrectinib 0 1
Repotrectinib Repotrectinib 32 5
Repotrectinib + SCH772984 Repotrectinib SCH772984 0 0
Repotrectinib + Sotorasib Repotrectinib Sotorasib 0 0
Repotrectinib + Trametinib Repotrectinib Trametinib 0 1
Repotrectinib + Ulixertinib Repotrectinib Ulixertinib 0 0


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