SN-38
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| Drug Name | SN-38 |
| Trade Name | |
| Synonyms | SN 38|SN38 |
| Drug Descriptions |
SN-38 is a metabolite of the topoisomerase inhibitor irinotecan, which causes cell cycle arrest and apoptotic induction, potentially leading to tumor growth inhibition (PMID: 21609311). |
| DrugClasses | TOPO Inhibitor (Pan) 3 |
| CAS Registry Number | 86639-52-3 |
| NCIT ID | C61618 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| BAY-293 + SN-38 | BAY-293 SN-38 | 0 | 0 |
| CHIR-124 + SN-38 | CHIR-124 SN-38 | 2 | 0 |
| Niraparib + SN-38 | Niraparib SN-38 | 0 | 0 |
| Olaparib + SN-38 | Olaparib SN-38 | 0 | 0 |
| Olaparib + SN-38 + Temozolomide | Olaparib SN-38 Temozolomide | 0 | 0 |
| SN-38 | SN-38 | 0 | 0 |
| SN-38 + Talazoparib | SN-38 Talazoparib | 0 | 0 |
| SN-38 + Veliparib | SN-38 Veliparib | 0 | 0 |
| SN-38 + VX-803 | SN-38 VX-803 | 0 | 0 |
| SN-38 + XRD-0394 | SN-38 XRD-0394 | 0 | 0 |
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