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Drug Name Copanlisib
Trade Name Aliqopa
Synonyms BAY80-6946|BAY806946
Drug Descriptions

Aliqopa (copanlisib) is a selective PIK3CA and PIK3CD inhibitor that prevents activation of Akt, resulting in inhibition of cell cycle progression and increased apoptosis (PMID: 24013662, PMID: 25528022). Aliqopa (copanlisib) is FDA approved for adult patients with follicular lymphoma (FDA.gov).

DrugClasses PIK3CA inhibitor 24 PIK3CD inhibitor 27
CAS Registry Number 1032568-63-0
NCIT ID C96796

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Copanlisib + Fulvestrant Abemaciclib Copanlisib Fulvestrant 0 1
Avelumab + Copanlisib Avelumab Copanlisib 0 1
Bendamustine + Copanlisib + Rituximab Bendamustine Copanlisib Rituximab 0 2
Carboplatin + Copanlisib + Dexamethasone + Gemcitabine + Pegfilgrastim + Rituximab Carboplatin Copanlisib Dexamethasone Gemcitabine Pegfilgrastim Rituximab 0 1
Cisplatin + Copanlisib + Gemcitabine Cisplatin Copanlisib Gemcitabine 0 1
Copanlisib Copanlisib 19 13
Copanlisib + Crizotinib Copanlisib Crizotinib 0 0
Copanlisib + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Rituximab + Vincristine Sulfate Copanlisib Cyclophosphamide Doxorubicin Etoposide Prednisone Rituximab Vincristine Sulfate 0 1
Copanlisib + Cyclophosphamide + Doxorubicin + Prednisolone + Rituximab + Vincristine Sulfate Copanlisib Cyclophosphamide Doxorubicin Prednisolone Rituximab Vincristine Sulfate 0 1
Copanlisib + Degarelix Copanlisib Degarelix 0 1
Copanlisib + Durvalumab Copanlisib Durvalumab 0 1
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
Copanlisib + Elimusertib Copanlisib Elimusertib 0 1
Copanlisib + ERAS-007 Copanlisib ERAS-007 1 0
Copanlisib + Eribulin Copanlisib Eribulin 0 1
Copanlisib + Fulvestrant Copanlisib Fulvestrant 0 2
Copanlisib + Ibrutinib Copanlisib Ibrutinib 0 3
Copanlisib + Imatinib Copanlisib Imatinib 3 0
Copanlisib + Ipilimumab + Nivolumab Copanlisib Ipilimumab Nivolumab 0 1
Copanlisib + Letrozole Copanlisib Letrozole 0 1
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
Copanlisib + Neratinib Copanlisib Neratinib 2 0
Copanlisib + Niraparib Copanlisib Niraparib 0 1
Copanlisib + Nivolumab Copanlisib Nivolumab 3 6
Copanlisib + Nivolumab + Rituximab Copanlisib Nivolumab Rituximab 0 1
Copanlisib + Obinutuzumab Copanlisib Obinutuzumab 0 1
Copanlisib + Olaparib Copanlisib Olaparib 0 1
Copanlisib + Paclitaxel Copanlisib Paclitaxel 1 1
Copanlisib + Pertuzumab + Trastuzumab Copanlisib Pertuzumab Trastuzumab 0 1
Copanlisib + Refametinib Copanlisib Refametinib 0 1
Copanlisib + Rituximab Copanlisib Rituximab 0 2
Copanlisib + Rogaratinib Copanlisib Rogaratinib 0 1
Copanlisib + Romidepsin Copanlisib Romidepsin 0 1
Copanlisib + Rucaparib Copanlisib Rucaparib 0 1
Copanlisib + Sotorasib Copanlisib Sotorasib 0 0
Copanlisib + Trastuzumab Copanlisib Trastuzumab 0 0
Copanlisib + Vemurafenib Copanlisib Vemurafenib 0 1
Copanlisib + Venetoclax Copanlisib Venetoclax 0 2


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