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Drug Name Lifirafenib
Trade Name
Synonyms BGB-283
Drug Descriptions

Lifirafenib (BGB-283) is a dual RAF kinase and EGFR inhibitor, which may lead to decreased tumor cell proliferation and reduced growth of tumors with activation of BRAF and/or EGFR (PMID: 26208524, PMID: 32182156).

DrugClasses BRAF Inhibitor 25 EGFR Inhibitor (Pan) 62
CAS Registry Number 1446090-79-4
NCIT ID C124995

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + Lifirafenib Cetuximab Lifirafenib 1 0
Lifirafenib Lifirafenib 12 1
Lifirafenib + MK-8353 Lifirafenib MK-8353 2 0
Lifirafenib + PD-0325901 Lifirafenib PD-0325901 3 1
Lifirafenib + Pimasertib Lifirafenib Pimasertib 1 0
Lifirafenib + SCH772984 Lifirafenib SCH772984 3 0
Lifirafenib + Selumetinib Lifirafenib Selumetinib 0 0
Lifirafenib + Trametinib Lifirafenib Trametinib 4 0
Lifirafenib + Ulixertinib Lifirafenib Ulixertinib 2 0
Lifirafenib + Vemurafenib Lifirafenib Vemurafenib 2 0


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