Drug Detail

Drug Name	Bosutinib
Trade Name	Bosulif
Synonyms	SKI-606\|PF-5208763
Drug Descriptions	Bosulif (bosutinib) inhibits SRC and ABL kinases and has additional activity against other kinases including AXL, TNK2, and BTK, resulting in decreased pathway activation and inhibition of tumor cell proliferation (PMID: 12543790, PMID: 19039322, PMID: 26555154). Bosulif (bosutinib) is FDA-approved for use in adult and pediatric patients 1 year of age and older with Ph+ (BCR-ABL) chronic myelogenous leukemia (FDA.gov).
DrugClasses	ABL Inhibitor (pan) 9 AXL Inhibitor 30 BCR-ABL Inhibitor 32 BTK inhibitor 37 SRC Inhibitor 31 TNK2 Inhibitor 6
CAS Registry Number	380843-75-4
NCIT ID	C60809

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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
Atezolizumab + Bosutinib	Atezolizumab Bosutinib	0	1
Axitinib + Bosutinib	Axitinib Bosutinib	0	1
Bosutinib	Bosutinib	1	13
Bosutinib + Cisplatin	Bosutinib Cisplatin	0	0
Bosutinib + Fulvestrant + Palbociclib	Bosutinib Fulvestrant Palbociclib	0	1
Bosutinib + Gemcitabine	Bosutinib Gemcitabine	0	0
Bosutinib + Glasdegib	Bosutinib Glasdegib	0	1
Bosutinib + Inotuzumab ozogamicin	Bosutinib Inotuzumab ozogamicin	0	1
Bosutinib + Olverembatinib	Bosutinib Olverembatinib	0	1
Bosutinib + Osimertinib	Bosutinib Osimertinib	0	0
Bosutinib + Osimertinib + PF-573228	Bosutinib Osimertinib PF-573228	0	0
Bosutinib + Palbociclib	Bosutinib Palbociclib	0	1
Bosutinib + Pemetrexed Disodium	Bosutinib Pemetrexed Disodium	0	1
Bosutinib + Rociletinib	Bosutinib Rociletinib	0	0
Bosutinib + Ropeginterferon	Bosutinib Ropeginterferon	0	1
Bosutinib + Ruxolitinib	Bosutinib Ruxolitinib	0	2
Bosutinib + SHP099	Bosutinib SHP099	0	0
Bosutinib + TAK-632	Bosutinib TAK-632	0	0
Bosutinib + Vemurafenib	Bosutinib Vemurafenib	1	0