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Showing 1 to 23 of 23 entries

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02933736	Phase 0	Ribociclib	Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients	Active, not recruiting	USA	0
NCT03114527	Phase II	Everolimus + Ribociclib	Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)	Active, not recruiting	USA	0
NCT03155620	Phase II	Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib	Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)	Active, not recruiting	USA \| CAN \| AUS	1
NCT04391595	Phase I	Abemaciclib + LY3214996	LY3214996 Plus Abemaciclib in Recurrent Glioblastoma Patients	Active, not recruiting	USA	0
NCT01356628	Phase II	Palbociclib	A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer	Completed	USA	0
NCT02555189	Phase Ib/II	Ribociclib Enzalutamide	Enzalutamide With and Without Ribociclib for Metastatic, Castrate-Resistant, Chemotherapy-Naive Prostate Cancer That Retains RB Expression	Completed	USA	0
NCT02599363	Phase I	Paclitaxel + Ribociclib	A Trial of Ribocilcib (LEE011) and Weekly Paclitaxel in Patients With Rb+ Advanced Breast Cancer	Completed	USA	0
NCT03009201	Phase I	Doxorubicin + Ribociclib	Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery	Completed	USA	0
NCT03110744	Phase II	Palbociclib	CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601)	Completed	DEU	0
NCT03355794	Phase I	Everolimus + Ribociclib	A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)	Completed	USA	0
NCT03526250	Phase II	Palbociclib	Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial)	Completed	USA	1
NCT03834740	Phase I	Everolimus + Ribociclib	A Phase 0 /II Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for Resection	Completed	USA	0
NCT04040205	Phase II	Abemaciclib	Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration	Recruiting	USA	0
NCT05940493	Phase II	Abemaciclib	Abemaciclib in Newly Diagnosed Meningioma Patients	Recruiting	USA	0
NCT02030483	Phase I	Palbociclib Dexamethasone Lenalidomide	Palbociclib in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma	Terminated	USA	0
NCT02255461	Phase I	Palbociclib	Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors	Terminated	USA	0
NCT02334527	Phase II	Palbociclib	Phase II Trial of Palbociclib (PD-0332991) in Patients With Metastatic Urothelial Cancer (UC) After Failure of First-Line Chemotherapy	Terminated	USA	0
NCT02524119	Phase II	Ribociclib	LEE001 and Chemoembolization In Patients With Advanced Hepatocellular Carcinoma (LEE001)	Terminated	USA	0
NCT03130439	Phase II	Abemaciclib	Abemaciclib for Patients With Retinoblastoma-Positive, Triple Negative Metastatic Breast Cancer	Terminated	USA	0
NCT03535506	Phase II	Palbociclib	Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery (WI223281)	Terminated	USA	0
NCT03781960	Phase II	Abemaciclib + Nivolumab	Abemaciclib and Nivolumab for Subjects With Hepatocellular Carcinoma	Terminated	USA	0
NCT01522989	Phase I	Fluorouracil + Oxaliplatin + Palbociclib	PD-0332991, 5-FU, and Oxaliplatin for Advanced Solid Tumor Malignancies	Unknown status	USA	0
NCT04316169	Phase I	Abemaciclib + Anastrozole + Hydroxychloroquine Abemaciclib + Fulvestrant + Hydroxychloroquine Abemaciclib + Hydroxychloroquine Abemaciclib + Hydroxychloroquine + Letrozole	Hydroxychloroquine, Abemaciclib and Endocrine Therapy in Hormone Receptor Positive (HR+)/Her 2 Negative Breast Cancer	Withdrawn	USA	0

Showing 1 to 23 of 23 entries

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Profile Name	RB1 positive
Gene Variant Detail	RB1 positive (unknown)
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