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Drug Detail
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| Drug Name | Molibresib |
| Trade Name | |
| Synonyms | I-BET762|GSK525762|GSK-525762|GSK 525762 |
| Drug Descriptions |
Molibresib (GSK525762) is a JQ1 derivative which binds to the bromodomain of BET proteins preventing their interaction with acetylated histone peptides, thus disrupting chromatin remodeling, gene expression, and cell proliferation (PMID: 24015967, PMID: 30906568, PMID: 32328561). |
| DrugClasses | BET Inhibitor (Pan) 32 |
| CAS Registry Number | 1260907-17-2 |
| NCIT ID | C101538 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Abiraterone + Molibresib | Abiraterone Molibresib | 0 | 1 |
| Bortezomib + Molibresib | Bortezomib Molibresib | 0 | 0 |
| Carfilzomib + Molibresib | Carfilzomib Molibresib | 0 | 0 |
| Enzalutamide + Molibresib | Enzalutamide Molibresib | 0 | 1 |
| Fulvestrant + Molibresib | Fulvestrant Molibresib | 0 | 1 |
| Molibresib | Molibresib | 1 | 2 |
| Molibresib + Paclitaxel + unspecified PD-L1 antibody | Molibresib Paclitaxel unspecified PD-L1 antibody | 0 | 0 |
| Molibresib + Palbociclib | Molibresib Palbociclib | 0 | 0 |
| Molibresib + Rucaparib | Molibresib Rucaparib | 0 | 0 |
| Molibresib + Selumetinib | Molibresib Selumetinib | 0 | 0 |
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