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| Drug Name | Ivosidenib |
| Trade Name | Tibsovo |
| Synonyms | AG-120 |
| Drug Descriptions |
Tibsovo (ivosidenib) inhibits mutant IDH1, leading to increased differentiation and decreased proliferation in IDH1 positive tumors (PMID: 27245312). Tibsovo (ivosidenib) is FDA approved for adult patients with relapsed or refractory IDH1-mutant (R132C/G/H/L/S) acute myeloid leukemia (AML) or myelodysplastic syndrome, patients 75 years or older with newly diagnosed IDH1-mutant AML, in combination with Vidaza (azacitidine) for patients with newly-diagnosed IDH1-mutant AML, and patients with advanced or metastatic IDH1-mutant cholangiocarcinoma (FDA.gov). |
| DrugClasses | IDH1 Inhibitor 8 |
| CAS Registry Number | 1448347-49-6 |
| NCIT ID | C114383 |
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