MLN4924
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| Drug Name | MLN4924 |
| Trade Name | Pevonedistat |
| Synonyms | MLN-4924 |
| Drug Descriptions |
Pevonedistat (MLN4924) binds and inhibits NEDD8, a ubiquitin-like protein, leading to inhibition of NFKB signaling, reduced transcription of target genes, and increased apoptosis in cancer cells with increased NFKB activity (PMID: 24634471, PMID: 29781056, PMID: 32721435). |
| DrugClasses | |
| CAS Registry Number | 905579-51-3 |
| NCIT ID | C77906 |
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