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Drug Name LY3214996
Trade Name
Synonyms Temuterkib|LY-3214996|LY 3214996
Drug Descriptions

LY3214996 inhibits ERK1/2, potentially resulting in decreased growth of tumors with alterations in the RAS/MAPK pathway (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4973, PMID: 31744895).

DrugClasses ERK Inhibitor (pan) 21
CAS Registry Number 1951483-29-6
NCIT ID C131335

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Cetuximab + LY3214996 Abemaciclib Cetuximab LY3214996 0 1
Abemaciclib + LY3214996 Abemaciclib LY3214996 1 3
Cetuximab + LY3214996 Cetuximab LY3214996 0 1
Gemcitabine + LY3214996 + Nab-paclitaxel Gemcitabine LY3214996 Nab-paclitaxel 0 1
Hydroxychloroquine + LY3214996 Hydroxychloroquine LY3214996 0 1
Ibrutinib + LY3214996 Ibrutinib LY3214996 0 1
LSN3074753 + LY3214996 LSN3074753 LY3214996 0 0
LY3009120 + LY3214996 LY3009120 LY3214996 3 0
LY3023414 + LY3214996 LY3023414 LY3214996 0 0
LY3214996 LY3214996 11 3
LY3214996 + LY3537982 LY3214996 LY3537982 0 1
LY3214996 + Midazolam LY3214996 Midazolam 0 1
LY3214996 + RMC-4550 LY3214996 RMC-4550 0 0
LY3214996 + RMC-4630 LY3214996 RMC-4630 0 1
LY3214996 + SCH772984 LY3214996 SCH772984 0 0
LY3214996 + Trametinib LY3214996 Trametinib 3 0


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