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| Drug Name | Evorpacept |
| Trade Name | |
| Synonyms | ALX-148|ALX 148|ALX148 |
| Drug Descriptions |
Evorpacept (ALX148) is a chimeric protein consisting of the Fc region of immunoglobulin fused to the CD47 SIRPa-binding domain, that blocks the ability of CD47 to bind SIRPa on macrophages thereby promoting phagocytosis of tumor cells (PMID: 28286286), and may also stimulate cytotoxic T-cells (PMID: 29873856). |
| DrugClasses | CD47 Antibody 31 Immune Checkpoint Inhibitor 149 |
| CAS Registry Number | NA |
| NCIT ID | C132851 |
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