Enfortumab vedotin-ejfv
Drug Detail
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| Drug Name | Enfortumab vedotin-ejfv |
| Trade Name | Padcev |
| Synonyms | AGS-22ME|Enfortumab vedotin|AGS-22M6E|ASG-22CE |
| Drug Descriptions |
Padcev (enfortumab vedotin-ejfv) is an antibody-drug conjugate (ADC) that fuses together a human antibody against NECTIN4 and monomethyl auristatin E, which may result in inhibition of tumor growth and tumor regression (PMID: 27013195). Padcev (enfortumab vedotin-ejfv) is FDA approved for use in patients with locally advanced or metastatic urothelial cancer who have previously received a PD-1 or PD-L1 inhibitor, and a platinum-containing chemotherapy, or who are ineligible for cisplatin-containing chemotherapy and have previously received one or more prior lines of therapy, in combination with Keytruda (pembrolizumab) for patients with locally advanced or metastatic urothelial carcinoma ineligible for cisplatin-containing chemotherapy, and in combination with Keytruda (pembrolizumab) or Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) as neoadjuvant treatment for cisplatin-ineligible patients with muscle invasive bladder cancer (FDA.gov). |
| DrugClasses | NECTIN4 Antibody 11 |
| CAS Registry Number | 1346452-25-2 |
| NCIT ID | C114500 |
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