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Drug Name lutetium Lu 177 dotatate
Trade Name Lutathera
Synonyms LuTate|177Lu-Octreotate|177 Lu-DOTA-Tyr3-octreotate
Drug Descriptions

Lutathera (lutetium Lu 177 dotatate) is a radiolabeled somatostatin analog which may selectively kill somatostatin receptor-positive tumor cells (PMID: 28076709). Lutathera (lutetium Lu 177 dotatate) is FDA approved for use in patients with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (FDA.gov).

DrugClasses
CAS Registry Number 437608-50-9
NCIT ID C95020

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIBG + lutetium Lu 177 dotatate 131I-MIBG lutetium Lu 177 dotatate 0 1
Atezolizumab + Carboplatin + Etoposide + lutetium Lu 177 dotatate Atezolizumab Carboplatin Etoposide lutetium Lu 177 dotatate 0 1
Avelumab + lutetium Lu 177 dotatate Avelumab lutetium Lu 177 dotatate 0 1
Cabozantinib + lutetium Lu 177 dotatate Cabozantinib lutetium Lu 177 dotatate 0 1
Carboplatin + Etoposide + lutetium Lu 177 dotatate + Tislelizumab Carboplatin Etoposide Tislelizumab lutetium Lu 177 dotatate 0 0
Decitabine and Cedazuridine + lutetium Lu 177 dotatate Decitabine and Cedazuridine lutetium Lu 177 dotatate 0 1
Fulvestrant + lutetium Lu 177 dotatate Fulvestrant lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate lutetium Lu 177 dotatate 0 17
lutetium Lu 177 dotatate + Nivolumab Nivolumab lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Octreotide acetate Octreotide acetate lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Olaparib Olaparib lutetium Lu 177 dotatate 0 3
lutetium Lu 177 dotatate + Pembrolizumab Pembrolizumab lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Peposertib Peposertib lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Sunitinib Sunitinib lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Talazoparib Talazoparib lutetium Lu 177 dotatate 0 1
lutetium Lu 177 dotatate + Triapine Triapine lutetium Lu 177 dotatate 0 2


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