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Drug Name ONO-7475
Trade Name
Synonyms ONO7475
Drug Descriptions

ONO-7475 inhibits AXL, MERTK, FLT3, and TYRO3, potentially leading to reduced growth and increased apoptosis of tumor cells (PMID: 28912176, PMID: 30501104, PMID: 31953310).

DrugClasses AXL Inhibitor 30 FLT3 Inhibitor 69 MERTK Inhibitor 13 TYRO3 Inhibitor 8
CAS Registry Number 1646839-59-9
NCIT ID C136822

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + ONO-7475 + S63845 Afatinib ONO-7475 S63845 0 0
Afatinib + ONO-7475 + Verteporfin Afatinib ONO-7475 Verteporfin 0 0
Cytarabine + ONO-7475 Cytarabine ONO-7475 0 0
Erlotinib + ONO-7475 + S63845 Erlotinib ONO-7475 S63845 0 0
Erlotinib + ONO-7475 + Verteporfin Erlotinib ONO-7475 Verteporfin 0 0
Gefitinib + ONO-7475 + S63845 Gefitinib ONO-7475 S63845 0 0
Gefitinib + ONO-7475 + Verteporfin Gefitinib ONO-7475 Verteporfin 0 0
Infigratinib + ONO-7475 + Osimertinib Infigratinib ONO-7475 Osimertinib 0 0
Lazertinib + ONO-7475 Lazertinib ONO-7475 0 0
Lazertinib + ONO-7475 + S63845 Lazertinib ONO-7475 S63845 0 0
Lazertinib + ONO-7475 + Verteporfin Lazertinib ONO-7475 Verteporfin 0 0
ONO-7475 ONO-7475 1 1
ONO-7475 + Osimertinib + Pemigatinib ONO-7475 Osimertinib Pemigatinib 0 0
ONO-7475 + Osimertinib + S63845 ONO-7475 Osimertinib S63845 0 0
ONO-7475 + Osimertinib + Trametinib ONO-7475 Osimertinib Trametinib 0 0
ONO-7475 + Osimertinib + Verteporfin ONO-7475 Osimertinib Verteporfin 0 0
ONO-7475 + Venetoclax ONO-7475 Venetoclax 1 0


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