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Drug Name Verteporfin
Trade Name Visudyne
Synonyms
Drug Descriptions

Visudyne (verteporfin) is a small molecule that binds to YAP1 and inhibits the interaction between YAP1 and TEAD, potentially resulting in decreased growth of YAP-driven tumor cells (PMID: 22677547, PMID: 28576749). Verteporfin is FDA-approved for treatment of age-related macular degeneration (FDA.gov).

DrugClasses YAP Inhibitor 3
CAS Registry Number 129497-78-5
NCIT ID C1014

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + ONO-7475 + Verteporfin Afatinib ONO-7475 Verteporfin 0 0
Afatinib + Verteporfin Afatinib Verteporfin 0 0
Erlotinib + ONO-7475 + Verteporfin Erlotinib ONO-7475 Verteporfin 0 0
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Pembrolizumab + Verteporfin Fluorouracil Irinotecan Leucovorin Oxaliplatin Pembrolizumab Verteporfin 0 1
Gefitinib + ONO-7475 + Verteporfin Gefitinib ONO-7475 Verteporfin 0 0
ICG-001 + Verteporfin ICG-001 Verteporfin 0 0
Lazertinib + ONO-7475 + Verteporfin Lazertinib ONO-7475 Verteporfin 0 0
MK2206 + Verteporfin MK2206 Verteporfin 0 0
ONO-7475 + Osimertinib + Verteporfin ONO-7475 Osimertinib Verteporfin 0 0
Pictilisib + Verteporfin Pictilisib Verteporfin 0 0
Verteporfin Verteporfin 0 5


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