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Drug Name Infigratinib
Trade Name Truseltiq
Synonyms BGJ398|BGJ-398|BGJ 398
Drug Descriptions

Truseltiq (infigratinib) is a pan-FGFR inhibitor, which inhibits tumor angiogenesis and tumor cell proliferation (PMID: 31109923, PMID: 30101387). Truseltiq (infigratinib) is FDA approved for use in patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 26
CAS Registry Number 872511-34-7
NCIT ID C88302

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + Infigratinib ABT-737 Infigratinib 3 0
Afatinib + Infigratinib Afatinib Infigratinib 0 0
Alpelisib + Infigratinib Alpelisib Infigratinib 2 1
Atezolizumab + Bevacizumab + Infigratinib Atezolizumab Bevacizumab Infigratinib 0 1
Binimetinib + Encorafenib + Infigratinib Binimetinib Encorafenib Infigratinib 0 1
Buparlisib + Infigratinib Buparlisib Infigratinib 1 0
Cabozantinib + Infigratinib Cabozantinib Infigratinib 0 0
Cisplatin + Gemcitabine + Infigratinib + Nab-paclitaxel Cisplatin Gemcitabine Infigratinib Nab-paclitaxel 0 1
Crizotinib + Infigratinib Crizotinib Infigratinib 0 0
Dasatinib + Infigratinib Dasatinib Infigratinib 4 0
Deltarasin + Infigratinib Deltarasin Infigratinib 0 0
Encorafenib + Infigratinib Encorafenib Infigratinib 0 1
Fluorouracil + Infigratinib Fluorouracil Infigratinib 0 0
Fluorouracil + Infigratinib + Irinotecan + Oxaliplatin Fluorouracil Infigratinib Irinotecan Oxaliplatin 0 1
Fulvestrant + Infigratinib + Palbociclib Fulvestrant Infigratinib Palbociclib 0 1
Ganetespib + Infigratinib Ganetespib Infigratinib 0 0
Gefitinib + Infigratinib Gefitinib Infigratinib 0 0
Ibrutinib + Infigratinib Ibrutinib Infigratinib 0 0
Imatinib + Infigratinib Imatinib Infigratinib 6 1
Infigratinib Infigratinib 178 15
Infigratinib + Lapatinib Infigratinib Lapatinib 0 0
Infigratinib + Navitoclax Infigratinib Navitoclax 1 0
Infigratinib + Olaparib Infigratinib Olaparib 0 0
Infigratinib + ONO-7475 + Osimertinib Infigratinib ONO-7475 Osimertinib 0 0
Infigratinib + Oxaliplatin Infigratinib Oxaliplatin 0 0
Infigratinib + Pelitinib Infigratinib Pelitinib 0 0
Infigratinib + Pictilisib Infigratinib Pictilisib 1 0
Infigratinib + Sapanisertib Infigratinib Sapanisertib 0 0
Infigratinib + Talazoparib Infigratinib Talazoparib 0 0
Infigratinib + Tamoxifen Infigratinib Tamoxifen 0 1
Infigratinib + Tepotinib Infigratinib Tepotinib 0 0
Infigratinib + Trabectedin Infigratinib Trabectedin 1 0
Infigratinib + Trametinib Infigratinib Trametinib 6 0
Infigratinib + Vandetanib Infigratinib Vandetanib 0 0


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