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Drug Name Liposomal irinotecan
Trade Name Onivyde
Synonyms PEP02|nal-IRI|MM-398|Irinotecan Sucrosofate
Drug Descriptions

Onivyde (liposomal irinotecan) comprises irinotecan encapsulated in liposomal nanoparticles, which may result in increased tumor growth inhibition (PMID: 23406728, PMID: 16540680, PMID: 29945562). Onivyde (liposomal irinotecan) in combination with chemotherapy is FDA-approved for use in patients with metastatic pancreatic adenocarcinoma (FDA.gov).

DrugClasses TOPO1 inhibitor 11
CAS Registry Number 1361317-83-0
NCIT ID C82676

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD0901 + Liposomal irinotecan AZD0901 Liposomal irinotecan 0 1
Bevacizumab + Liposomal irinotecan Bevacizumab Liposomal irinotecan 0 1
Bevacizumab + Liposomal irinotecan + Trifluridine-tipiracil hydrochloride Bevacizumab Liposomal irinotecan Trifluridine-tipiracil hydrochloride 0 1
BKT140 + Fluorouracil + Leucovorin + Liposomal irinotecan + Pembrolizumab BKT140 Fluorouracil Leucovorin Liposomal irinotecan Pembrolizumab 0 0
Cyclophosphamide + Liposomal irinotecan Cyclophosphamide Liposomal irinotecan 0 1
Fluorouracil + Leucovorin + Liposomal irinotecan Fluorouracil Leucovorin Liposomal irinotecan 0 2
Fluorouracil + Leucovorin + Liposomal irinotecan + Onvansertib Fluorouracil Leucovorin Liposomal irinotecan Onvansertib 0 1
Fluorouracil + Leucovorin + Liposomal irinotecan + Rucaparib Fluorouracil Leucovorin Liposomal irinotecan Rucaparib 0 1
Fluorouracil + Leucovorin + Liposomal irinotecan + Sotorasib Fluorouracil Leucovorin Liposomal irinotecan Sotorasib 0 1
Fluorouracil + Liposomal irinotecan Fluorouracil Liposomal irinotecan 0 1
Fluorouracil + Liposomal irinotecan + Oxaliplatin Fluorouracil Liposomal irinotecan Oxaliplatin 0 1
Fluorouracil + Liposomal irinotecan + Oxaliplatin + Trastuzumab Fluorouracil Liposomal irinotecan Oxaliplatin Trastuzumab 0 1
Fluorouracil + Liposomal irinotecan + SHR-1316 Fluorouracil Liposomal irinotecan SHR-1316 0 0
Liposomal irinotecan Liposomal irinotecan 0 0
Liposomal irinotecan + Pembrolizumab Liposomal irinotecan Pembrolizumab 0 1
Liposomal irinotecan + Ramucirumab Liposomal irinotecan Ramucirumab 0 1
Liposomal irinotecan + Trifluridine-tipiracil hydrochloride Liposomal irinotecan Trifluridine-tipiracil hydrochloride 0 1
Liposomal irinotecan + Veliparib Liposomal irinotecan Veliparib 0 1


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