Molecular Profile Detail

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Showing 1 to 33 of 33 entries

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01396408	Phase II	Temsirolimus Sunitinib	A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours	Active, not recruiting	CAN	0
NCT03531736	Phase I	Rituximab Cyclophosphamide + Fludarabine	T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia	Active, not recruiting	USA	0
NCT03674411	Phase II	Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Cyclophosphamide + Filgrastim + Fludarabine + MGTA-456 + Mycophenolate mofetil + Tacrolimus	Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy	Active, not recruiting	USA	0
NCT04591431	Phase II	Everolimus Nivolumab Itacitinib Erlotinib Ponatinib Pemigatinib Ipatasertib Ipilimumab Cobimetinib Atezolizumab Palbociclib Entrectinib Vemurafenib Lapatinib Trastuzumab Brigatinib Alectinib Ado-trastuzumab emtansine Pertuzumab Vismodegib	The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy (ROME)	Active, not recruiting	ITA	0
NCT04773782	Phase Ib/II	Avapritinib	A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling	Active, not recruiting	USA \| ITA \| GBR \| FRA \| DEU \| CAN \| AUT \| AUS	1
NCT01028222	Phase II	Nilotinib	A Study of AMNN107 in the Treatment of Metastatic and/or Inoperable Melanoma Harboring a c-Kit Mutation	Completed	USA \| SWE \| NLD \| ITA \| ESP \| DEU \| CHE \| CAN \| BRA \| BEL \| AUS \| ARG	2
NCT01306045	Phase II	Erlotinib Lapatinib MK2206 Sunitinib Selumetinib	Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies	Completed	USA	0
NCT01338987	Phase II	Tacrolimus Busulfan Methotrexate Leuprolide Cyclophosphamide Fludarabine	Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation	Completed	USA	0
NCT01738139	Phase I	Imatinib + Ipilimumab	Ipilimumab and Imatinib Mesylate in Advanced Cancer	Completed	USA	0
NCT01831726	Phase II	Dovitinib	Dovitinib for Patients With Tumor Pathway Activations Inhibited by Dovitinib	Completed	USA	0
NCT02015065	Phase II	Vandetanib	Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors	Completed	USA	0
NCT02401815	Phase Ib/II	PLX9486 + Sunitinib Pexidartinib + PLX9486 PLX9486	PLX9486 as a Single Agent and in Combination With PLX3397 or PLX9486 With Sunitinib in Patients With Advanced Solid Tumors	Completed	USA	0
NCT02561988	Phase I	Avapritinib	(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies	Completed	USA \| GBR	0
NCT04059224	Phase II	Dabrafenib + Trametinib	TraMel-WT: A Trial of Trametinib in Patients With Advanced Pretreated BRAFV600 Wild-type Melanoma (TraMel-WT)	Completed	BEL	0
NCT04908176	Phase I	Avapritinib + Midazolam	A Drug-drug Interaction Study of Avapritinib and Midazolam	Completed	USA	0
NCT02029001	Phase II	Durvalumab + Tremelimumab Olaparib Nilotinib	Adapting Treatment to the Tumor Molecular Alterations for Patients With Advanced Solid Tumors: MyOwnSpecificTreatment (MOST plus)	Recruiting	FRA	0
NCT02693535	Phase II	Cobimetinib + Vemurafenib Atezolizumab + Talazoparib Regorafenib Larotrectinib Trastuzumab + Tucatinib Futibatinib Ipilimumab + Nivolumab Palbociclib Entrectinib Talazoparib Pembrolizumab Temsirolimus Pertuzumab + Trastuzumab Atezolizumab + Pertuzumab/trastuzumab/hyaluronidase-zzxf Abemaciclib Sunitinib Olaparib	TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR)	Recruiting	USA	0
NCT03613532	Phase I	Azacitidine + Venetoclax Busulfan + Fludarabine + Venetoclax Decitabine and Cedazuridine	Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN	Recruiting	USA	0
NCT03934372	Phase Ib/II	Ponatinib	Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors	Recruiting	SWE \| NLD \| ITA \| GBR \| FRA \| ESP \| DNK \| DEU \| BEL	0
NCT04598009	Phase II	Binimetinib + Imatinib	Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma	Recruiting	USA	0
NCT04936178	Phase I	NB003	A Study of NB003 in Patients with Advanced Malignancies	Recruiting	USA \| GBR \| FRA \| ESP	2
NCT05493215	Phase II	Imatinib	Imatinib TDM in GIST	Recruiting	USA	0
NCT05957367	Phase Ib/II	Inlexisertib + Ripretinib	A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies	Recruiting	USA	0
NCT06630234	Phase Ib/II	DCC-3009	A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)	Recruiting	USA	0
NCT06655246	Phase I	Imatinib + Ziftomenib	A Study of Ziftomenib, an Oral Menin Inhibitor, in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)	Recruiting	USA	0
NCT05441514	Phase I	Cobimetinib + Enasidenib	Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia	Suspended	USA	0
NCT02315625	Phase II	Everolimus Sunitinib	Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive Surgery	Terminated	USA	0
NCT05160168	Phase Ib/II	THE-630	A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)	Terminated	USA	0
NCT02400385	Phase II	Nivolumab + Sunitinib	A Phase II Trial of Sunitinib and Nivolumab for KIT-mutated Advanced Melanoma	Withdrawn	USA	0
NCT02747537	Phase II	Irinotecan + Sorafenib	Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors With Sorafenib in Combination With Irinotecan	Withdrawn		0
NCT02812693	Phase Ib/II	Imatinib + Pembrolizumab	Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification	Withdrawn		0
NCT03109301	Phase II	Selumetinib	A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)	Withdrawn		0
NCT03365661	Phase II	Nogapendekin alfa inbakicept	QUILT-3.034: Non-Myeloablative TCRa/b Deplete Haplo HSCT With Post ALT-803 for AML	Withdrawn	USA	0

Showing 1 to 33 of 33 entries

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Profile Name	KIT mutant
Gene Variant Detail	KIT mutant (unknown)
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