soft tissue sarcoma
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ID DOID:0070663
Name soft tissue sarcoma
Definition A connective tissue cancer that has_material_basis_in abnormally proliferating cells derived from embryonic mesoderm and starts in the soft tissues of the body (e.g. fat, muscle, nerves, blood vessels).
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer soft tissue sarcoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
RET fusion Selpercatinib soft tissue sarcoma sensitive detail...
MLH1 negative Pembrolizumab soft tissue sarcoma sensitive detail...
MSH6 negative Pembrolizumab soft tissue sarcoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03138161 Phase Ib/II Ipilimumab + Nivolumab + Trabectedin Trabectedin, Ipilimumab and Nivolumab as First Line Treatment for Advanced Soft Tissue Sarcoma Recruiting USA 0
NCT03242382 Phase II Palbociclib Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc) Recruiting ESP 0
NCT03784014 Phase III Ceritinib Dabrafenib + Trametinib Capmatinib Durvalumab + Olaparib Nilotinib Futibatinib Trametinib Palbociclib Glasdegib Lapatinib Molecular Profiling of Advanced Soft-tissue Sarcomas (MULTISARC) Active, not recruiting FRA 0
NCT04095208 Phase II Nivolumab + Relatlimab Nivolumab Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study (CONGRATS) Active, not recruiting FRA 0
NCT04595994 Phase I Gemcitabine + Selinexor Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma and Osteosarcoma (SeliSarc) Recruiting ESP 0
NCT04650984 Phase III Doxorubicin + Onfekafusp alfa Doxorubicin A Study Comparing the Efficacy of L19TNF+Doxorubicin vs Doxorubicin Alone as First-line Therapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma (FIBROSARC) Recruiting POL | ITA | FRA | ESP | DEU 0
NCT05809830 Phase Ib/II Doxorubicin Doxorubicin + LB-100 Phase I/II of LB-100 Plus Doxorubicin vs. Doxorubicin Alone in First Line of Advanced Soft Tissue Sarcomas (Enhancer) Active, not recruiting ESP 0
NCT06239272 Phase Ib/II Selinexor Pazopanib Doxorubicin + Ifosfamide NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Recruiting USA 0
NCT06474676 Phase I AttIL12 T-cells Cyclophosphamide T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients. Recruiting USA 0
NCT06797999 Phase Ib/II ADCE-D01 First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma (ADCElerate1) Recruiting USA | GBR | FRA | DEU | BEL 0