Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Duvelisib
Trade Name Copiktra
Synonyms IPI-145|INK1197
Drug Descriptions

Copiktra (duvelisib) prevents the activation of the PI3K delta/gamma-mediated signaling pathways, resulting in tumor cell death (PMID: 25258342). Copiktra (duvelisib) is FDA approved for use in adult patients with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma (FDA.gov)

DrugClasses PIK3CD inhibitor 27 PIK3CG inhibitor 10
CAS Registry Number 1201438-56-3
NCIT ID C99225

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Duvelisib Acalabrutinib Duvelisib 0 1
Azacitidine + Doxorubicin + Duvelisib + Romidepsin Azacitidine Doxorubicin Duvelisib Romidepsin 0 1
Azacitidine + Duvelisib Azacitidine Duvelisib 0 1
Bortezomib + Duvelisib Bortezomib Duvelisib 0 1
Cyclophosphamide + Doxorubicin + Duvelisib + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Duvelisib Etoposide Prednisone Vincristine Sulfate 0 1
Docetaxel + Duvelisib Docetaxel Duvelisib 0 1
Duvelisib Duvelisib 3 14
Duvelisib + Ibrutinib Duvelisib Ibrutinib 0 1
Duvelisib + Nivolumab Duvelisib Nivolumab 0 3
Duvelisib + Obinutuzumab Duvelisib Obinutuzumab 0 1
Duvelisib + Pembrolizumab Duvelisib Pembrolizumab 0 1
Duvelisib + Rituximab Duvelisib Rituximab 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Duvelisib + Ruxolitinib Duvelisib Ruxolitinib 0 1
Duvelisib + unspecified PD-L1 antibody Duvelisib unspecified PD-L1 antibody 0 0
Duvelisib + Venetoclax Duvelisib Venetoclax 0 2


Additional content available in CKB BOOST