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Drug Name Romidepsin
Trade Name Istodax
Synonyms FK228|FR901228|NSC 630176|depsipeptide
Drug Descriptions

Istodax (romidepsin) inhibits Class I HDACs, resulting in cell cycle arrest, apoptosis, and decreased tumor cell growth (PMID: 12208741, PMID: 12234611, PMID: 21258344). Istodax (romidepsin) is FDA approved for patients with cutaneous T-cell lymphoma (FDA.gov).

DrugClasses HDAC Inhibitor 45
CAS Registry Number 128517-07-7
NCIT ID C1544

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Dexamethasone + Lenalidomide + Romidepsin Azacitidine Dexamethasone Lenalidomide Romidepsin 0 1
Azacitidine + Doxorubicin + Duvelisib + Romidepsin Azacitidine Doxorubicin Duvelisib Romidepsin 0 1
Azacitidine + Durvalumab + Romidepsin Azacitidine Durvalumab Romidepsin 0 1
Azacitidine + Gemcitabine + Nab-paclitaxel + Romidepsin Azacitidine Gemcitabine Nab-paclitaxel Romidepsin 0 1
Azacitidine + Pembrolizumab + Romidepsin Azacitidine Pembrolizumab Romidepsin 0 1
Azacitidine + Romidepsin Azacitidine Romidepsin 0 3
Brentuximab vedotin + Romidepsin Brentuximab vedotin Romidepsin 0 1
Busulfan + Fludarabine + Romidepsin Busulfan Fludarabine Romidepsin 0 1
Cisplatin + Nivolumab + Romidepsin Cisplatin Nivolumab Romidepsin 0 1
Cisplatin + Romidepsin Cisplatin Romidepsin 0 1
Copanlisib + Romidepsin Copanlisib Romidepsin 0 1
Cytarabine + Romidepsin Cytarabine Romidepsin 1 0
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Durvalumab + Romidepsin Durvalumab Romidepsin 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Gemcitabine + Nab-paclitaxel + Romidepsin Gemcitabine Nab-paclitaxel Romidepsin 0 1
Ixazomib + Romidepsin Ixazomib Romidepsin 0 1
Lenalidomide + Rituximab + Romidepsin Lenalidomide Rituximab Romidepsin 0 1
Lenalidomide + Romidepsin Lenalidomide Romidepsin 0 1
LY2409881 + Romidepsin LY2409881 Romidepsin 0 0
MK2206 + Romidepsin MK2206 Romidepsin 0 0
Parsaclisib + Romidepsin Parsaclisib Romidepsin 0 1
Pegylated liposomal doxorubicin + Romidepsin Pegylated liposomal doxorubicin Romidepsin 0 1
Pembrolizumab + Romidepsin Pembrolizumab Romidepsin 0 2
Pralatrexate + Romidepsin Pralatrexate Romidepsin 0 1
Romidepsin Romidepsin 1 10
Romidepsin + Tenalisib Romidepsin Tenalisib 0 1
Romidepsin + Trametinib Romidepsin Trametinib 1 0


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