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Gene | HRAS |
Variant | Q61G |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS Q61G does not lie within any known functional domains of the Hras protein (UniProt.org). Q61G results in decreased Hras GTPase activity in an in vitro assay and is weakly transforming in culture (PMID: 3510078), and therefore, is predicted to lead to a loss of Hras protein function and activation of downstream signaling. |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS Q61G HRAS mutant HRAS Q61X HRAS Q61G |
Transcript | NM_005343.4 |
gDNA | chr11:g.533874_533875delCAinsGG |
cDNA | c.181_182delCAinsGG |
Protein | p.Q61G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |