Molecular Profile Detail

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Showing 1 to 25 of 25 entries

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02867592	Phase II	Cabozantinib	Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors	Active, not recruiting	USA	0
NCT03155620	Phase II	Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib	Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)	Active, not recruiting	USA \| CAN \| AUS	1
NCT03899792	Phase Ib/II	Selpercatinib	A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors (LIBRETTO-121)	Active, not recruiting	USA \| ITA \| GBR \| FRA \| ESP \| DNK \| DEU \| CAN \| AUS	2
NCT04211337	Phase III	Vandetanib Cabozantinib Selpercatinib	A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531)	Active, not recruiting	USA \| POL \| NLD \| ITA \| ISR \| GRC \| GBR \| FRA \| ESP \| DEU \| CZE \| CAN \| BRA \| BEL \| AUS	5
NCT04320888	Phase II	Selpercatinib	Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial	Active, not recruiting	USA \| AUS	1
NCT04526691	Phase I	Cisplatin + Datopotamab deruxtecan + Pembrolizumab Carboplatin + Datopotamab deruxtecan + Pembrolizumab Datopotamab deruxtecan + Pembrolizumab	Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)	Active, not recruiting	USA \| ITA \| ESP	2
NCT04759911	Phase II	Selpercatinib	Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer	Active, not recruiting	USA	0
NCT05241834	Phase I	LOXO-260	A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment	Active, not recruiting	USA \| FRA	0
NCT05687266	Phase III	Carboplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Paclitaxel + Pembrolizumab Carboplatin + Datopotamab deruxtecan + Durvalumab Cisplatin + Pembrolizumab + Pemetrexed Disodium	Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations (AVANZAR)	Active, not recruiting	USA \| TUR \| SWE \| POL \| ITA \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CAN \| BRA \| BGR \| AUT	8
NCT03906331	Expanded access	Selpercatinib	Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation	Approved for marketing	USA \| POL \| NZL \| ITA \| ISR \| FRA \| ESP \| DEU \| CHE \| AUS	3
NCT02272998	Phase II	Ponatinib	Ponatinib for Patients Whose Advanced Solid Tumor Cancer Has Activating Mutations Involving the Following Genes: FGFR1, FGFR2, FGFR3, FGFR4, RET, KIT.	Completed	USA	0
NCT03953235	Phase Ib/II	GRT-C903 + GRT-R904 + Ipilimumab + Nivolumab	A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens	Completed	USA	0
NCT06946797	Phase II	Paclitaxel Cisplatin Pemetrexed Disodium Carboplatin Ipilimumab + Nivolumab	A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC) (CheckMate-1533)	Not yet recruiting	USA \| TUR \| ROU \| POL \| ITA \| GRC \| FRA \| BRA	3
NCT02925234	Phase II	Crizotinib Sunitinib Niraparib Olaparib Lorlatinib Erdafitinib Talazoparib Dacomitinib Axitinib Panitumumab	The Drug Rediscovery Protocol (DRUP Trial) (DRUP)	Recruiting	NLD	0
NCT03175224	Phase Ib/II	Vebreltinib	APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA)	Recruiting	USA \| ITA \| HUN \| GBR \| FRA \| FIN \| ESP \| CAN \| AUS	4
NCT04116541	Phase II	Alectinib Regorafenib Dabrafenib + Trametinib Cabozantinib Avapritinib	A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/characteristics in Advanced / Metastatic Tumors. (MegaMOST)	Recruiting	FRA	0
NCT04631744	Phase II	Cabozantinib	Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC)	Recruiting	USA	0
NCT05159245	Phase II	Vemurafenib Tepotinib Vismodegib Apalutamide Alectinib Regorafenib Entrectinib Pertuzumab + Trastuzumab Pemigatinib Atezolizumab Cobimetinib Dabrafenib + Trametinib Dabrafenib Trametinib Abemaciclib	The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs (FINPROVE)	Recruiting	FIN	0
NCT05176665	Phase Ib/II	EMB-01	EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers	Recruiting	USA	1
NCT06458036	Phase II	Selpercatinib	Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE) (RAISE)	Recruiting	USA	0
NCT06561386	Phase III	Carboplatin + Pembrolizumab + Pemetrexed Disodium Cisplatin + Nivolumab + Pemetrexed Disodium + Relatlimab Cisplatin + Pembrolizumab + Pemetrexed Disodium Carboplatin + Nivolumab + Pemetrexed Disodium + Relatlimab	A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 1-49% (RELATIVITY1093)	Recruiting	USA \| TUR \| ROU \| POL \| NZL \| NLD \| ITA \| IRL \| GBR \| FRA \| ESP \| DNK \| DEU \| CHE \| BRA \| BEL \| AUT \| AUS \| ARG	11
NCT02949843	Phase II	Nivolumab + Pembrolizumab	Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations	Terminated	USA	0
NCT03131206	Phase Ib/II	Alectinib	A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer	Terminated	USA	0
NCT04161391	Phase Ib/II	TPX-0046	Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations	Terminated	USA	1
NCT05435846	Phase I	Capmatinib + Trametinib	Capmatinib Plus Trametinib for the Treatment of Metastatic Non-small Cell Lung Cancer With MET Exon 14 Skipping Mutation	Terminated	USA	0

Showing 1 to 25 of 25 entries

Filter rows:

Profile Name	RET act mut
Gene Variant Detail	RET act mut (gain of function)
Relevant Treatment Approaches	RET Inhibitor

Molecular Profile Detail

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