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Drug Name Brentuximab vedotin
Trade Name Adcetris
Synonyms SGN-35
Drug Descriptions

Adcetris (brentuximab vedotin) is an antibody-drug conjugate (ADC) comprised of a monoclonal antibody targeting CD30 linked to the tubulin-binding drug MMAE, which binds CD30-expressing cells and disrupts microtubule polymerization, potentially resulting in decreased tumor growth (PMID: 22684302). Adcetris (brentuximab vedotin) is FDA approved for Hodgkin lymphoma, anaplastic large cell lymphoma, CD30-expressing mycosis fungoides, and in combination with chemotherapy in other CD30-expressing peripheral T-cell lymphomas (FDA.gov).

DrugClasses
CAS Registry Number 914088-09-8
NCIT ID C66944

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alisertib + Brentuximab vedotin Alisertib Brentuximab vedotin 0 1
Bendamustine + Brentuximab vedotin Bendamustine Brentuximab vedotin 0 3
Bendamustine + Brentuximab vedotin + Rituximab Bendamustine Brentuximab vedotin Rituximab 0 1
Bevacizumab + Brentuximab vedotin Bevacizumab Brentuximab vedotin 0 1
Bleomycin + Brentuximab vedotin + Dacarbazine + Doxorubicin + Nivolumab + Vinblastine Bleomycin Brentuximab vedotin Dacarbazine Doxorubicin Nivolumab Vinblastine 0 1
Brentuximab vedotin Brentuximab vedotin 1 16
Brentuximab vedotin + Carboplatin + Etoposide + Ifosfamide Brentuximab vedotin Carboplatin Etoposide Ifosfamide 0 1
Brentuximab vedotin + Ceritinib Brentuximab vedotin Ceritinib 0 1
Brentuximab vedotin + Cisplatin + Cytarabine + Dexamethasone + Rituximab Brentuximab vedotin Cisplatin Cytarabine Dexamethasone Rituximab 0 1
Brentuximab vedotin + Crizotinib Brentuximab vedotin Crizotinib 0 0
Brentuximab vedotin + Cyclophosphamide + Dacarbazine + Dexamethasone + Doxorubicin + Etoposide Brentuximab vedotin Cyclophosphamide Dacarbazine Dexamethasone Doxorubicin Etoposide 0 1
Brentuximab vedotin + Cyclophosphamide + Dacarbazine + Doxorubicin + Etoposide + Prednisone Brentuximab vedotin Cyclophosphamide Dacarbazine Doxorubicin Etoposide Prednisone 0 0
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone Brentuximab vedotin Cyclophosphamide Doxorubicin Etoposide Prednisone 0 3
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Brentuximab vedotin Cyclophosphamide Doxorubicin Etoposide Prednisone Vincristine Sulfate 0 0
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Nivolumab + Prednisone + Rituximab Brentuximab vedotin Cyclophosphamide Doxorubicin Nivolumab Prednisone Rituximab 0 2
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Pralatrexate + Prednisone Brentuximab vedotin Cyclophosphamide Doxorubicin Pralatrexate Prednisone 0 1
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Prednisone Brentuximab vedotin Cyclophosphamide Doxorubicin Prednisone 0 1
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Prednisone + Rituximab Brentuximab vedotin Cyclophosphamide Doxorubicin Prednisone Rituximab 0 1
Brentuximab vedotin + Cyclosporine + Verapamil Brentuximab vedotin Cyclosporine Verapamil 0 1
Brentuximab vedotin + Dacarbazine Brentuximab vedotin Dacarbazine 0 1
Brentuximab vedotin + Dacarbazine + Doxorubicin + Filgrastim + Vinblastine Brentuximab vedotin Dacarbazine Doxorubicin Filgrastim Vinblastine 0 2
Brentuximab vedotin + Dacarbazine + Doxorubicin + Nivolumab Brentuximab vedotin Dacarbazine Doxorubicin Nivolumab 0 1
Brentuximab vedotin + Dacarbazine + Doxorubicin + Nivolumab + Rituximab + Vinblastine Brentuximab vedotin Dacarbazine Doxorubicin Nivolumab Rituximab Vinblastine 0 1
Brentuximab vedotin + Dacarbazine + Doxorubicin + Nivolumab + Vinblastine Brentuximab vedotin Dacarbazine Doxorubicin Nivolumab Vinblastine 0 2
Brentuximab vedotin + Dacarbazine + Doxorubicin + Pembrolizumab Brentuximab vedotin Dacarbazine Doxorubicin Pembrolizumab 0 1
Brentuximab vedotin + Dacarbazine + Doxorubicin + Rituximab + Vinblastine Brentuximab vedotin Dacarbazine Doxorubicin Rituximab Vinblastine 0 1
Brentuximab vedotin + Dacarbazine + Doxorubicin + Vinblastine Brentuximab vedotin Dacarbazine Doxorubicin Vinblastine 0 4
Brentuximab vedotin + Doxorubicin + Rituximab + Vincristine Sulfate Brentuximab vedotin Doxorubicin Rituximab Vincristine Sulfate 0 1
Brentuximab vedotin + Doxorubicin + Vincristine Sulfate Brentuximab vedotin Doxorubicin Vincristine Sulfate 0 1
Brentuximab vedotin + Ibrutinib Brentuximab vedotin Ibrutinib 0 1
Brentuximab vedotin + Ipilimumab Brentuximab vedotin Ipilimumab 0 1
Brentuximab vedotin + Lenalidomide Brentuximab vedotin Lenalidomide 0 1
Brentuximab vedotin + Lenalidomide + Rituximab Brentuximab vedotin Lenalidomide Rituximab 0 1
Brentuximab vedotin + Mocetinostat Brentuximab vedotin Mocetinostat 0 1
Brentuximab vedotin + Mogamulizumab Brentuximab vedotin Mogamulizumab 0 1
Brentuximab vedotin + Nivolumab Brentuximab vedotin Nivolumab 0 11
Brentuximab vedotin + Nivolumab + Rituximab + Vinblastine Brentuximab vedotin Nivolumab Rituximab Vinblastine 0 1
Brentuximab vedotin + Pembrolizumab Brentuximab vedotin Pembrolizumab 0 5
Brentuximab vedotin + Rituximab Brentuximab vedotin Rituximab 0 1
Brentuximab vedotin + Romidepsin Brentuximab vedotin Romidepsin 0 1
Brentuximab vedotin + Umbralisib Brentuximab vedotin Umbralisib 0 0


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