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Drug Name Epacadostat
Trade Name
Synonyms INCB024360|INCB 024360|INCB-024360
Drug Descriptions

Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent conversion of tryptophan to kynurenine, potentially resulting in increased proliferation of T-cells and natural killer cells and enhanced anti-tumor immune response (PMID: 20197554).

DrugClasses IDO1 Inhibitor 12
CAS Registry Number 1204669-58-8
NCIT ID C92582

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Epacadostat Atezolizumab Epacadostat 0 1
Avelumab + Bevacizumab + Epacadostat Avelumab Bevacizumab Epacadostat 0 0
Azacitidine + Epacadostat + Pembrolizumab Azacitidine Epacadostat Pembrolizumab 0 1
Bevacizumab + Epacadostat + Radiotherapy + Retifanlimab Bevacizumab Epacadostat Radiotherapy Retifanlimab 0 1
Bintrafusp alfa + Epacadostat + FPV-Brachyury + MVA-BN-Brachyury + Nogapendekin alfa inbakicept Bintrafusp alfa Epacadostat FPV-Brachyury MVA-BN-Brachyury Nogapendekin alfa inbakicept 0 1
Carboplatin + Cisplatin + Epacadostat + Fluorouracil + Nivolumab Carboplatin Cisplatin Epacadostat Fluorouracil Nivolumab 0 1
Carboplatin + Cisplatin + Epacadostat + Gemcitabine + Nivolumab + Paclitaxel + Pemetrexed Disodium Carboplatin Cisplatin Epacadostat Gemcitabine Nivolumab Paclitaxel Pemetrexed Disodium 0 1
Carboplatin + Epacadostat + Paclitaxel + Pembrolizumab Carboplatin Epacadostat Paclitaxel Pembrolizumab 0 2
Carboplatin + Epacadostat + Pembrolizumab + Pemetrexed Disodium Carboplatin Epacadostat Pembrolizumab Pemetrexed Disodium 0 2
Cisplatin + Epacadostat + Pembrolizumab + Pemetrexed Disodium Cisplatin Epacadostat Pembrolizumab Pemetrexed Disodium 0 1
CRS-207 + Cyclophosphamide + Epacadostat + GVAX pancreatic cancer vaccine + Pembrolizumab CRS-207 Cyclophosphamide Epacadostat GVAX pancreatic cancer vaccine Pembrolizumab 0 1
CRS-207 + Epacadostat + Pembrolizumab CRS-207 Epacadostat Pembrolizumab 0 1
Cyclophosphamide + Epacadostat + Maveropepimut-S Cyclophosphamide Epacadostat Maveropepimut-S 0 1
Cyclophosphamide + Epacadostat + Pembrolizumab Cyclophosphamide Epacadostat Pembrolizumab 0 1
Durvalumab + Epacadostat Durvalumab Epacadostat 0 2
Epacadostat Epacadostat 0 8
Epacadostat + Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin Epacadostat Fluorouracil Leucovorin Nivolumab Oxaliplatin 0 1
Epacadostat + Gemcitabine + Nab-paclitaxel + Nivolumab Epacadostat Gemcitabine Nab-paclitaxel Nivolumab 0 1
Epacadostat + INCAGN01876 + Pembrolizumab Epacadostat INCAGN01876 Pembrolizumab 0 1
Epacadostat + INCB001158 Epacadostat INCB001158 0 1
Epacadostat + INCB001158 + Pembrolizumab Epacadostat INCB001158 Pembrolizumab 0 1
Epacadostat + Ipilimumab + Nivolumab Epacadostat Ipilimumab Nivolumab 0 1
Epacadostat + Itacitinib Epacadostat Itacitinib 0 1
Epacadostat + Lirilumab + Nivolumab Epacadostat Lirilumab Nivolumab 0 1
Epacadostat + Nivolumab Epacadostat Nivolumab 0 2
Epacadostat + OATD-02 + unspecified PD-L1 antibody Epacadostat OATD-02 unspecified PD-L1 antibody 0 0
Epacadostat + Pembrolizumab Epacadostat Pembrolizumab 0 20
Epacadostat + Pembrolizumab + Tavokinogene telseplasmid Epacadostat Pembrolizumab Tavokinogene telseplasmid 0 1
Epacadostat + Retifanlimab Epacadostat Retifanlimab 0 3
Epacadostat + SD-101 Epacadostat SD-101 0 1
Epacadostat + Sirolimus Epacadostat Sirolimus 0 1


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