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Drug Name | Elacestrant |
Trade Name | Orserdu |
Synonyms | RAD1901 |
Drug Descriptions |
Orserdu (elacestrant) is a selective estrogen receptor degrader that down-regulates ER and ER-regulated genes, resulting in anti-tumor activity and may be effective in cells resistant to CDK4/6 inhibitors (PMID: 28473534, PMID: 31852484). Orserdu (elacestrant) is FDA approved for use in postmenopausal women or adult men with ER-positive, ERBB2 (HER2)-negative, ESR1 (ER alpha)-mutated advanced or metastatic breast cancer progressed on endocrine therapy (FDA.gov). |
DrugClasses | Hormone - Anti-estrogens 29 |
CAS Registry Number | 722533-56-4 |
NCIT ID | C120211 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Abemaciclib + Elacestrant | Abemaciclib Elacestrant | 0 | 4 |
Alpelisib + Elacestrant | Alpelisib Elacestrant | 0 | 1 |
Elacestrant | Elacestrant | 0 | 8 |
Elacestrant + Everolimus | Elacestrant Everolimus | 0 | 1 |
Elacestrant + Fulvestrant | Elacestrant Fulvestrant | 0 | 0 |
Elacestrant + MEN1611 | Elacestrant MEN1611 | 0 | 0 |
Elacestrant + MEN2312 | Elacestrant MEN2312 | 0 | 1 |
Elacestrant + Niraparib | Elacestrant Niraparib | 0 | 1 |
Elacestrant + Onapristone | Elacestrant Onapristone | 0 | 1 |
Elacestrant + Palbociclib | Elacestrant Palbociclib | 0 | 2 |
Elacestrant + Ribociclib | Elacestrant Ribociclib | 0 | 2 |
Elacestrant + Samuraciclib | Elacestrant Samuraciclib | 0 | 1 |
Elacestrant + Triptorelin | Elacestrant Triptorelin | 0 | 1 |