Molecular Profile Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02576444	Phase II	Adavosertib + Olaparib Olaparib Capivasertib + Olaparib Ceralasertib + Olaparib	OLAParib COmbinations (OLAPCO)	Terminated	USA	0
NCT02525692	Phase II	Dordaviprone	Oral ONC201 in Recurrent GBM, H3 K27M Glioma, and Midline Glioma	Terminated	USA	0
NCT02492737	Phase I	Vorasidenib	Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation	Completed	USA \| FRA	0
NCT03718767	Phase II	Nivolumab	Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype	Active, not recruiting	USA	0
NCT03881735	Phase II	Enasidenib	Enasidenib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia With an IDH2 Gene Mutation	Withdrawn	USA	0
NCT07301268	Phase II	GI-102 + Pembrolizumab GI-102	GI-102 Alone or in Combination With Pembrolizumab Before Surgery for the Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 Astrocytoma	Not yet recruiting	USA	0
NCT03212274	Phase II	Olaparib	Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations	Active, not recruiting	USA	0
NCT03139916	Phase II	Bavituximab + Temozolomide	Bavituximab With Radiation and Temozolomide for Patients With Newly Diagnosed Glioblastoma	Completed	USA	0
NCT04015700	Phase I	GNOS-PV01 + Rocakinogene sifuplasmid	Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma	Active, not recruiting	USA	0
NCT06258018	Phase Ib/II	Niraparib + Temozolomide	Niraparib and Temozolomide in Patients Glioblastoma (ONC-2022-001)	Not yet recruiting	ITA	0
NCT07089641	Phase I	ERAS-801	ERAS-801 for the Treatment of Resectable and Progressive or Recurrent IDH Wildtype Grade IV Glioblastoma or Astrocytoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial (ERAS801-SARG)	Recruiting	USA	0
NCT04559230	Phase II	Sacituzumab govitecan-hziy	Sacituzumab Govitecan in Recurrent Glioblastoma	Recruiting	USA	0
NCT03878095	Phase II	Ceralasertib + Olaparib	Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant Tumors	Active, not recruiting	USA	0
NCT05406700	Phase I	Niraparib	Niraparib In Recurrent IDH 1/2 Gliomas	Active, not recruiting	USA	0
NCT03047993	Phase Ib/II	Azacitidine + Telaglenastat	Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome	Completed	USA	0
NCT03744390	Phase II	Enasidenib	IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome	Active, not recruiting	FRA	0
NCT04555577	Phase I	Peposertib Temozolomide	Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma	Recruiting	USA	0
NCT05465954	Phase II	NT-I7 + Pembrolizumab	Efineptakin Alfa and Pembrolizumab for the Treatment of Recurrent Glioblastoma	Recruiting	USA	0
NCT02677922	Phase Ib/II	Azacitidine + Ivosidenib Azacitidine Azacitidine + Enasidenib	A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy	Active, not recruiting	USA \| SWE \| NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CHE \| CAN \| BEL \| AUS	2
NCT06831526	Phase I	Azeliragon + Temozolomide	Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma	Recruiting	USA	0
NCT07243470	Phase Ib/II	Tarlatamab + Temozolomide	Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors (TARLATEM)	Recruiting	FRA	0
NCT05474378	Phase I	Retroviral vector transduced B7-H3 CAR T cells	B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme	Recruiting	USA	0
NCT05432804	Phase Ib/II	Selinexor + Temozolomide Temozolomide	Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment	Suspended	USA	0
NCT05756777	Phase I	Gilteritinib + Ivosidenib Enasidenib + Gilteritinib	A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)	Recruiting	USA	0
NCT05401097	Phase II	Azacitidine + Enasidenib + Venetoclax Azacitidine + Ivosidenib + Venetoclax	IDH Targeted/non- Targeted Vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)	Recruiting	USA	0
NCT06809322	Phase III	Vorasidenib	Vorasidenib Maintenance for IDH Mutant Astrocytoma (VIGOR)	Not yet recruiting	NLD \| ITA \| GBR \| FRA \| ESP \| DEU \| CZE \| CHE \| BEL \| AUT	0
NCT05588141	Phase Ib/II	Zotiraciclib	A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations	Recruiting	USA	0
NCT04955938	Phase I	Enasidenib + Fedratinib Fedratinib + Ivosidenib	A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms	Withdrawn	USA	0
NCT05282459	Phase Ib/II	Enasidenib	Enasidenib in MDS &Non-proliferative Chronic Myelomonocytic Leukemia w/o IDH2 Mutation	Completed	USA	0
NCT05345002	Phase II	Retifanlimab + Tretinoin	All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma	Recruiting	USA	0
NCT02428855	Phase II	Dasatinib	Phase II Trial of Dasatinib in Patients With Isocitrate Dehydrogenase (IDH)-Mutant Advanced Intrahepatic Cholangiocarcinoma	Completed	USA	0
NCT06991101	Phase II	Ruxolitinib + Temozolomide Temozolomide	Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma	Recruiting	USA	0
NCT04396860	Phase II	Temozolomide Ipilimumab + Nivolumab	Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma	Active, not recruiting	USA	0
NCT03430791	Phase II	Ipilimumab + Nivolumab Nivolumab	Trial of Combination TTF(Optune), Nivolumab Plus/Minus Ipilimumab for Recurrent Glioblastoma	Terminated	USA	0
NCT07110246	Phase II	Dabrafenib + Trametinib	Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas (PNOC037)	Recruiting	USA	0
NCT03728335	Phase I	Enasidenib	Enasidenib (AG-221) Maintenance Post Allogeneic HCT in Patients With IDH2 Mutation	Recruiting	USA	0
NCT05283109	Phase I	P30-EPS + Poly ICLC	ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM (ETAPA I)	Active, not recruiting	USA	0
NCT05463848	Phase II	Olaparib + Pembrolizumab + Temozolomide Pembrolizumab	Surgical Pembro +/- Olaparib W TMZ for RGBM	Recruiting	USA	0
NCT02858895	Phase II	MDNA55	Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma	Completed	USA	0
NCT04203316	Phase II	Enasidenib	Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With an IDH2 Mutation	Active, not recruiting	USA \| CAN	0
NCT04118036	Phase II	Abemaciclib + Pembrolizumab	Abemaciclib + Pembrolizumab In Glioblastoma	Withdrawn	USA	0
NCT05441514	Phase I	Cobimetinib + Enasidenib	Enasidenib in Combination With Cobimetinib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia	Active, not recruiting	USA	0
NCT06297512	Phase II	Doxorubicin + Temozolomide	Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).	Recruiting	ITA	0
NCT05188508	Phase II	Olaparib + Pembrolizumab + Temozolomide	Pembrolizumab, Olaparib, and Temozolomide for People with Glioma	Recruiting	USA	0
NCT03991832	Phase II	Durvalumab + Olaparib	Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors (SOLID)	Recruiting	CAN	0
NCT03158389	Phase Ib/II	Vismodegib Alectinib Idasanutlin Temsirolimus Atezolizumab Palbociclib APG101	NCT Neuro Master Match - N²M² (NOA-20) (N²M²)	Completed	DEU	0
NCT06636162	Phase I	DSP-0390	Window of Opportunity Study of DSP-0390 in Gliomas	Recruiting	USA	0
NCT02968940	Phase II	Avelumab	Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma	Completed	USA	0
NCT05538572	Phase I	PRT3645	A Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors	Completed	USA	1
NCT05879120	Phase II	Pembrolizumab	Randomized Study of Neo-adjuvant and Adjuvant Pembrolizumab With and Without Targeted Blood Brain Barrier Opening Using Exablate MRI-guided Focused Ultrasound (Exablate MRgFUS) for Recurrent Glioblastoma	Withdrawn	USA	0
NCT01915498	Phase Ib/II	Enasidenib	Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation	Completed	USA \| FRA	0
NCT03825796	Phase II	CPX-351 + Enasidenib Cytarabine + Enasidenib Enasidenib	CPX-351 Plus Enasidenib for Relapsed AML	Active, not recruiting	USA	0
NCT04729959	Phase II	Atezolizumab + Tocilizumab	Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma	Active, not recruiting	USA	0
NCT06776250	Phase II	Tarlatamab	Study of How Safe and Effective Tarlatamab is in Brain Cancers	Recruiting	CAN	0
NCT03749187	Phase I	Pamiparib + Temozolomide	BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas (PNOC017)	Active, not recruiting	USA	0
NCT05743595	Phase I	Personalized cancer vaccine + Retifanlimab	Neoantigen-based Personalized DNA Vaccine With Retifanlimab PD-1 Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma	Recruiting	USA	0
NCT06095375	Phase I	Regorafenib + Temozolomide	Regorafenib With Temozolomide With or Without RT in MGMT-Methylated, IDH Wild-type GBM Patients (REGOMA-2)	Completed	ITA	0
NCT07177079	Phase I	Decitabine + Venetoclax Azacitidine + Venetoclax Azacitidine + Venetoclax + Vitamin C Decitabine + Venetoclax + Vitamin C	High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML)	Not yet recruiting	USA	0
NCT02632708	Phase I	Enasidenib + Etoposide + Mitoxantrone Cytarabine + Enasidenib Cytarabine + Idarubicin + Ivosidenib Cytarabine + Daunorubicin + Enasidenib Cytarabine + Enasidenib + Idarubicin Etoposide + Ivosidenib + Mitoxantrone Cytarabine + Ivosidenib Cytarabine + Daunorubicin + Ivosidenib	Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation	Active, not recruiting	USA \| NLD \| DEU	0
NCT05432375	Phase I	Tinostamustine	Study of Tinostamustine for Adjuvant Treatment of Glioblastoma	Completed	ESP \| CHE	0
NCT04606316	Phase I	Nivolumab Ipilimumab + Nivolumab	Surgical Nivolumab And Ipilimumab For Recurrent GBM	Active, not recruiting	USA	0
NCT06413706	Phase II	Abemaciclib + Temozolomide Temozolomide	A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy	Recruiting	USA \| ROU \| NLD \| ITA \| FRA \| ESP \| DNK \| BEL \| AUS	1
NCT05376800	Phase I	BI 907828	A Study to Determine How BI 907828 (Brigimadlin) is Taken up in the Tumor (Phase 0) and to Determine the Highest Dose of BI 907828 (Brigimadlin) That Could be Tolerated (Phase 1a) in Combination With Radiation Therapy in People With a Brain Tumor Called Glioblastoma	Completed	USA \| ESP \| BEL	0
NCT04988555	Phase Ib/II	DSP-5336	A Study of DSP-5336 in Relapsed/refractory AML/ ALL with or Without MLL Rearrangement or NPM1 Mutation	Recruiting	USA \| ITA \| GBR \| FRA \| ESP \| CAN \| BEL	4
NCT02577406	Phase III	Azacitidine Cytarabine Enasidenib	An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation (IDHENTIFY)	Completed	USA \| TUR \| ITA \| GBR \| FRA \| ESP \| DNK \| DEU \| CZE \| CAN \| BRA \| BEL \| AUT \| AUS	4
NCT03207347	Phase II	Niraparib	A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001)	Completed	USA	0
NCT04629209	Phase II	Dordaviprone	A Phase II, Open Label Study of ONC201 in Adults With EGFR-low Glioblastoma	Withdrawn	USA	0
NCT05052957	Phase II	Carmustine + Filgrastim + O6-benzylguanine + Temozolomide	hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) (hSTAR GBM)	Recruiting	USA	0
NCT06478212	Phase Ib/II	Temozolomide + Vorasidenib	Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma	Active, not recruiting	USA \| NLD \| ITA \| ISR \| GBR \| FRA \| ESP \| DEU \| AUT	2
NCT03683433	Phase II	Azacitidine + Enasidenib	Enasidenib and Azacitidine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia and IDH2 Gene Mutation	Recruiting	USA	0
NCT05627323	Phase I	CHM-1101	CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma	Active, not recruiting	USA	0
NCT04762602	Phase I	HMPL-306	A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations	Terminated	USA \| ESP	0
NCT06719362	Phase I	M3T01 M3T01 + Temozolomide M3T01 + Pembrolizumab Fluorouracil + Leucovorin + M3T01 + Oxaliplatin + Pembrolizumab	A Clinical Trial to Evaluate the Safety, Tolerability and Clinical Efficacy of M3T01 Monotherapy and in Combination With Pembrolizumab and Other Systemic Therapies	Recruiting	USA	0
NCT04774393	Phase Ib/II	Decitabine and Cedazuridine + Ivosidenib + Venetoclax Decitabine and Cedazuridine + Enasidenib + Venetoclax	Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia	Recruiting	USA	0
NCT04281498	Phase II	Enasidenib + Ruxolitinib	Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation	Completed	USA \| CAN	0
NCT04945148	Phase II	Metformin + Temozolomide	Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide (OPTIMUM)	Recruiting	ITA \| FRA	0
NCT04764474	Phase I	HMPL-306	A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH	Terminated	USA \| ESP	0
NCT03701295	Phase Ib/II	Azacitidine + Pinometostat	Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement	Completed	USA	0
NCT04908176	Phase I	Avapritinib + Midazolam	A Drug-drug Interaction Study of Avapritinib and Midazolam	Completed	USA	0
NCT05222802	Phase I	ERAS-801	A Study to Evaluate ERAS-801 in Patients With Recurrent Glioblastoma (THUNDERBBOLT-1)	Active, not recruiting	USA	0
NCT05183204	Phase II	GDC-0084 + Metformin	Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma	Suspended	USA	0
NCT07347210	Phase II	Temozolomide Temozolomide + UCPVax Pembrolizumab + Temozolomide + UCPVax	Evaluation of UCPVax Vaccine +/- Pembrolizumab Combined With Standard Treatment as Adjuvant Therapy in Patients With Unmethylated MGMT Glioblastoma (MATVAC-1)	Not yet recruiting	FRA	0
NCT05326464	Phase III	Tofacitinib	Tofacitinib in Recurrent GBM Patients	Active, not recruiting	USA	0
NCT02071862	Phase I	Everolimus + Telaglenastat Erlotinib + Telaglenastat Docetaxel + Telaglenastat Telaglenastat Paclitaxel + Telaglenastat Cabozantinib + Telaglenastat	Study of the Glutaminase Inhibitor CB-839 in Solid Tumors	Completed	USA	0
NCT06161974	Phase II	Olutasidenib + Temozolomide	Study of Olutasidenib and Temozolomide in HGG	Recruiting	USA \| NLD \| GBR \| DEU \| CAN \| AUS	0
NCT02273739	Phase Ib/II	Enasidenib	Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation	Completed	USA \| FRA	0
NCT03970447	Phase II	VAL-083 ADI-PEG 20 AZD1390 VT1021 Lomustine Regorafenib Temozolomide GDC-0084	A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma (GBM AGILE)	Recruiting	USA \| FRA \| DEU \| CHE \| CAN \| AUS	0
NCT02981940	Phase II	Abemaciclib	A Study of Abemaciclib in Recurrent Glioblastoma	Active, not recruiting	USA	0
NCT05417594	Phase Ib/II	AZD9574 + Trastuzumab deruxtecan AZD9574 + Datopotamab deruxtecan AZD9574 AZD9574 + Temozolomide	Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies (CERTIS1)	Recruiting	USA \| SWE \| GBR \| ESP \| DEU \| AUS	1
NCT03557359	Phase II	Nivolumab	Nivolumab for Recurrent or Progressive IDH Mutant Gliomas	Completed	USA	0
NCT03922555	Phase I	Decitabine and Cedazuridine	ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas	Recruiting	USA	0
NCT06934889	Phase I	ABBV-637 + ERAS-801 ABBV-637 + Temozolomide ERAS-801 + Mirzotamab clezutoclax Mirzotamab clezutoclax + Temozolomide	Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma	Recruiting	USA	0
NCT02481154	Phase I	Vorasidenib	Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation	Completed	USA	0
NCT07223034	Phase I	lutetium Lu 177 vipivotide tetraxetan + Temozolomide	A Study of 177Lu-PSMA-617 in People With Gliomas	Recruiting	USA	0

Profile Name	IDH2 mutant
Gene Variant Detail	IDH2 mutant (unknown)
Relevant Treatment Approaches

Molecular Profile Detail

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