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Drug Name KRT-232
Trade Name
Synonyms KRT 232|KRT232|AMG232|AMG 232|AMG-232|Navtemadlin
Drug Descriptions

KRT-232 (AMG 232) is a potent inhibitor of the MDM2-p53 interaction, and inhibits proliferation of tumor cells in a p53 dependent manner (PMID: 24456472, PMID: 32234759).

DrugClasses MDM2 Inhibitor 23
CAS Registry Number 1352066-68-2
NCIT ID C156415

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + KRT-232 Acalabrutinib KRT-232 0 1
Avelumab + KRT-232 Avelumab KRT-232 0 1
Carboplatin + KRT-232 Carboplatin KRT-232 1 0
Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide Carfilzomib Dexamethasone KRT-232 Lenalidomide 0 1
Cisplatin + KRT-232 Cisplatin KRT-232 1 0
Cytarabine + Idarubicin + KRT-232 Cytarabine Idarubicin KRT-232 0 1
Cytarabine + KRT-232 Cytarabine KRT-232 0 1
Dabrafenib + KRT-232 + Trametinib Dabrafenib KRT-232 Trametinib 2 1
Dasatinib + KRT-232 Dasatinib KRT-232 0 1
Dasatinib + KRT-232 + Nilotinib Dasatinib KRT-232 Nilotinib 0 0
Decitabine + KRT-232 Decitabine KRT-232 0 1
Decitabine + KRT-232 + Venetoclax Decitabine KRT-232 Venetoclax 0 1
Doxorubicin + KRT-232 Doxorubicin KRT-232 0 0
Irinotecan + KRT-232 Irinotecan KRT-232 0 0
KRT-232 KRT-232 15 11
KRT-232 + Navitoclax KRT-232 Navitoclax 1 0
KRT-232 + Nilotinib KRT-232 Nilotinib 0 1
KRT-232 + Osimertinib KRT-232 Osimertinib 0 0
KRT-232 + Pembrolizumab KRT-232 Pembrolizumab 0 0
KRT-232 + Radiotherapy KRT-232 Radiotherapy 6 0
KRT-232 + Ruxolitinib KRT-232 Ruxolitinib 0 1
KRT-232 + Selpercatinib KRT-232 Selpercatinib 0 0
KRT-232 + TL-895 KRT-232 TL-895 0 1
KRT-232 + Trametinib KRT-232 Trametinib 0 1


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