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Drug Name Ipatasertib
Trade Name
Synonyms GDC-0068|RG-7440
Drug Descriptions

Ipatasertib (GDC-0068) binds to and inhibits the activity of AKT in an ATP-competitive manner, which may result in the inhibition of the PI3K-AKT signaling pathway and tumor cell proliferation (PMID: 22934575, PMID: 32205017).

DrugClasses Akt Inhibitor (Pan) 21
CAS Registry Number 1001264-89-6
NCIT ID C91072

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1331852 + Ipatasertib A-1331852 Ipatasertib 0 0
Abiraterone + Ipatasertib Abiraterone Ipatasertib 2 1
Atezolizumab + Capecitabine + Ipatasertib Atezolizumab Capecitabine Ipatasertib 0 1
Atezolizumab + Docetaxel + Ipatasertib Atezolizumab Docetaxel Ipatasertib 0 1
Atezolizumab + Fulvestrant + Ipatasertib Atezolizumab Fulvestrant Ipatasertib 0 1
Atezolizumab + Ipatasertib Atezolizumab Ipatasertib 5 8
Atezolizumab + Ipatasertib + Nab-paclitaxel Atezolizumab Ipatasertib Nab-paclitaxel 0 1
Atezolizumab + Ipatasertib + Paclitaxel Atezolizumab Ipatasertib Paclitaxel 0 2
AZD0156 + Ipatasertib AZD0156 Ipatasertib 1 0
Capecitabine + Ipatasertib Capecitabine Ipatasertib 0 1
Carboplatin + Gemcitabine + Ipatasertib Carboplatin Gemcitabine Ipatasertib 0 1
Carboplatin + Ipatasertib Carboplatin Ipatasertib 0 1
Carboplatin + Ipatasertib + Paclitaxel Carboplatin Ipatasertib Paclitaxel 0 2
Cisplatin + Ipatasertib Cisplatin Ipatasertib 1 1
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 0 1
Darolutamide + Ipatasertib Darolutamide Ipatasertib 0 1
Docetaxel + Ipatasertib Docetaxel Ipatasertib 2 1
Enzalutamide + Ipatasertib Enzalutamide Ipatasertib 0 0
Eribulin + Ipatasertib Eribulin Ipatasertib 0 1
Fluorouracil + Ipatasertib + Leucovorin + Oxaliplatin Fluorouracil Ipatasertib Leucovorin Oxaliplatin 4 0
Fulvestrant + Ipatasertib Fulvestrant Ipatasertib 0 2
Fulvestrant + Ipatasertib + Lapatinib Fulvestrant Ipatasertib Lapatinib 0 0
Fulvestrant + Ipatasertib + Palbociclib Fulvestrant Ipatasertib Palbociclib 0 3
Giredestrant + Ipatasertib Giredestrant Ipatasertib 0 1
GSK2334470 + Ipatasertib GSK2334470 Ipatasertib 1 0
Ipatasertib Ipatasertib 22 10
Ipatasertib + KU-57788 Ipatasertib KU-57788 1 0
Ipatasertib + Megestrol acetate Ipatasertib Megestrol acetate 0 1
Ipatasertib + Navitoclax Ipatasertib Navitoclax 0 0
Ipatasertib + Onvansertib Ipatasertib Onvansertib 1 0
Ipatasertib + OSU-T315 Ipatasertib OSU-T315 2 0
Ipatasertib + Paclitaxel Ipatasertib Paclitaxel 7 8
Ipatasertib + Palbociclib Ipatasertib Palbociclib 2 0
Ipatasertib + Pembrolizumab Ipatasertib Pembrolizumab 0 1
Ipatasertib + Pertuzumab + Trastuzumab Ipatasertib Pertuzumab Trastuzumab 0 1
Ipatasertib + Ribociclib Ipatasertib Ribociclib 1 0
Ipatasertib + RMC-4550 + Sotorasib Ipatasertib RMC-4550 Sotorasib 0 0
Ipatasertib + Rucaparib Ipatasertib Rucaparib 0 1
Ipatasertib + SCH772984 Ipatasertib SCH772984 0 0
Ipatasertib + Selumetinib Ipatasertib Selumetinib 0 0
Ipatasertib + Sirolimus Ipatasertib Sirolimus 1 0
Ipatasertib + Temsirolimus Ipatasertib Temsirolimus 0 0
Ipatasertib + Torin 1 Ipatasertib Torin 1 1 0


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