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ID DOID:50749
Name peripheral T-cell lymphoma
Definition A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus.
Source DiseaseOntology.org
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Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer lymphoma non-Hodgkin lymphoma T-cell non-Hodgkin lymphoma mature T-cell and NK-cell lymphoma peripheral T-cell lymphoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
TP53 wild-type ALRN-6924 peripheral T-cell lymphoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01431209 Phase II Ruxolitinib Ruxolitinib Phosphate (Oral JAK Inhibitor INCB18424) in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma Completed USA 0
NCT01644253 Phase I Idelalisib + Otlertuzumab + Rituximab Otlertuzumab + Rituximab Obinutuzumab + Otlertuzumab Ibrutinib + Otlertuzumab Bendamustine + Otlertuzumab Phase 1b Safety and Efficacy Study of TRU-016 Terminated USA 0
NCT02181218 Phase I Pegfilgrastim Romidepsin Dexamethasone + Gemcitabine + Oxaliplatin Phase I Study of Romidepsin, Gemcitabine, Oxaliplatin, and Dexamethasone in Patients With Relapsed/Refractory Aggressive Lymphomas Completed USA 0
NCT02232516 Phase II Lenalidomide + Romidepsin Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma Active, not recruiting USA 0
NCT02273739 Phase Ib/II Enasidenib Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation Completed USA | FRA 0
NCT02440685 Phase Ib/II ASN002 A Phase 1/2 Study To Evaluate ASN002 In Relapsed/Refractory Lymphoma And Advanced Solid Tumors Terminated USA | ARG 0
NCT02464228 Phase II Tipifarnib Study of Tipifarnib in Subjects With Relapsed or Refractory Peripheral T-Cell Lymphoma Completed USA | ESP 1
NCT02495415 Phase II Fenretinide Trial of Intravenous Fenretinide Emulsion for Patients With Relapsed/Refractory Peripheral T-cell Lymphomas Unknown status USA 0
NCT02512497 Phase I Romidepsin Busulfan + Fludarabine + Romidepsin Romidepsin Maintenance After Allogeneic Stem Cell Transplantation Active, not recruiting USA 0
NCT02520791 Phase I MEDI-570 Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma Active, not recruiting USA | CAN 0
NCT02535247 Phase II Pembrolizumab Study of MK-3475 in Relapsed or Refractory Peripheral T-cell Non-Hodgkin Lymphoma Terminated USA 0
NCT02567656 Phase I Tenalisib Safety and Efficacy Study of a Dual PI3K Delta/Gamma Inhibitor in T-cell Lymphoma Completed USA 0
NCT02576496 Phase I Tinostamustine Study of EDO-S101, A First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies Completed USA | NLD | ITA | FRA | ESP | DEU | CHE 0
NCT02581631 Phase Ib/II Brentuximab vedotin + Nivolumab A Safety and Efficacy Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas (CheckMate 436) Completed USA | ITA | GBR | FRA | ESP | CAN 0
NCT02689453 Phase I Alemtuzumab + rhIL-15 Subcutaneous Recombinant Human IL-15 (s.c. rhIL-15) and Alemtuzumab for People With Refractory or Relapsed Chronic and Acute Adult T-cell Leukemia (ATL) Completed USA 0
NCT02797470 Phase Ib/II Carmustine + CCR5 shRNA/TRIM5a/TAR decoy-transduced CD34+ HPCs + Cytarabine + Etoposide + Melphalan Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant Active, not recruiting USA 0
NCT02875002 Phase I Belinostat + Volasertib Study of Volasertib and Belinostat in Patients With Relapsed and Refractory Aggressive B-cell and T-cell Lymphomas Withdrawn USA 0
NCT02978625 Phase II Nivolumab + Talimogene laherparepvec Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Active, not recruiting USA 0
NCT03011814 Phase Ib/II Durvalumab Durvalumab + Lenalidomide Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma Active, not recruiting USA 0
NCT03017820 Phase I VSV-hIFNbeta-NIS VSV-hIFNbeta-NIS in Treating Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia, or T-cell Lymphoma Recruiting USA 0
NCT03049449 Phase I Cyclophosphamide + Fludarabine 5F11-28Z CAR-T cells T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas Completed USA 0
NCT03075553 Phase II Nivolumab Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Terminated USA 0
NCT03081910 Phase I CD5 CAR-T cells Cyclophosphamide + Fludarabine Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen (MAGENTA) Recruiting USA 0
NCT03161223 Phase Ib/II Durvalumab + Romidepsin Azacitidine + Durvalumab Azacitidine + Durvalumab + Romidepsin Durvalumab + Pralatrexate + Romidepsin Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma Unknown status USA 0
NCT03217643 Phase II Brentuximab vedotin CHP-BV Followed by Consolidation With High-dose Therapy / ASCT as Frontline Treatment of Patients With EATL Type 1. (EATL-001) Completed FRA 0
NCT03218683 Phase I AZD5991 Study of AZD5991 in Relapsed or Refractory Haematologic Malignancies. Terminated USA 0
NCT03240211 Phase I Pembrolizumab + Pralatrexate Decitabine + Pembrolizumab + Pralatrexate Decitabine + Pembrolizumab Study of Pembrolizumab Combined With Decitabine and Pralatrexate in PTCL and CTCL Recruiting USA 0
NCT03264131 Phase II Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma Active, not recruiting USA 0
NCT03278782 Phase Ib/II Romidepsin Pembrolizumab + Romidepsin Study of Pembrolizumab (MK-3475) in Combination With Romidepsin Active, not recruiting USA 0
NCT03328104 Phase I Cyclophosphamide + Etoposide + Everolimus + Nelarabine Everolimus in Combination With Nelarabine, Cyclophosphamide and Etoposide in Lymphoblastic Leukemia/Lymphoma (ENCERT) Completed USA 0
NCT03372057 Phase II Duvelisib A Study of Duvelisib in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL) Completed USA | ITA | GBR | DEU 0
NCT03409432 Phase II Brentuximab vedotin + Lenalidomide Brentuximab Vedotin and Lenalidomide in Treating Patients With Stage IB-IVB Relapsed or Refractory T-Cell Lymphoma Active, not recruiting USA 0
NCT03422679 Phase Ib/II CB-103 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Terminated USA | FRA | ESP | DEU | CHE 1
NCT03534180 Phase II Venetoclax Venetoclax in Treating Participants With Recurrent or Refractory Mature T-Cell Lymphoma Completed USA 0
NCT03547700 Phase Ib/II Ixazomib + Romidepsin Study of Ixazomib and Romidepsin in Peripheral T-cell Lymphoma (PTCL) Active, not recruiting USA 0
NCT03586999 Phase Ib/II Cyclophosphamide + Doxorubicin + Etoposide + Nivolumab + Prednisone + Vincristine Sulfate Nivolumab With Standard of Care Chemotherapy for Peripheral T Cell Lymphomas Completed USA 0
NCT03590574 Phase Ib/II AUTO4 Phase I/II Study Evaluating AUTO4 in Patients With TRBC1 Positive T Cell Lymphoma Active, not recruiting GBR | ESP 0
NCT03598998 Phase Ib/II Pembrolizumab + Pralatrexate Pembrolizumab and Pralatrexate in Treating Participants With Relapsed or Refractory Peripheral T-Cell Lymphomas Active, not recruiting USA 0
NCT03601819 Phase I Pacritinib Pacritinib in Relapsed/Refractory Lymphoproliferative Disorders Terminated USA 0
NCT03674411 Phase II Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Cyclophosphamide + Filgrastim + Fludarabine + MGTA-456 + Mycophenolate mofetil + Tacrolimus Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy Active, not recruiting USA 0
NCT03719105 Phase I Pembrolizumab Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Pralatrexate + Prednisone Calaspargase pegol-mknl + Dexamethasone + Etoposide + Ifosfamide + Methotrexate Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma Recruiting USA 0
NCT03829540 Phase I CD4CAR CD4CAR for CD4+ Leukemia and Lymphoma Recruiting USA 0
NCT03900442 Phase I GGTI-2418 Phase 1 Study of PTX-100 in Patients With Advanced Malignancies Unknown status AUS 0
NCT03902184 Phase II Gemcitabine + Lacutamab + Oxaliplatin Lacutamab IPH4102 Alone or in Combination With Chemotherapy in Patients With Advanced T Cell Lymphoma (TELLOMAK) Active, not recruiting USA | POL | ITA | FRA | ESP | DEU | BEL | AUT 0
NCT03905135 Phase I Avelumab + rhIL-15 Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies Completed USA 0
NCT03921879 Phase I OT-82 Safety and Efficacy of OT-82 in Participants With Relapsed or Refractory Lymphoma Unknown status USA 0
NCT03927105 Phase II Cabiralizumab + Nivolumab Nivolumab and the Antagonistic CSF-1R Monoclonal Antibody Cabiralizumab (BMS-986227) in Patients With Relapsed/Refractory Peripheral T Cell Lymphoma Completed USA 0
NCT03947255 Phase II Brentuximab vedotin A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma Terminated USA 0
NCT04018248 Phase I BR101801 BR101801 in Adult Patients With Advanced Hematologic Malignancies( Phase I) Active, not recruiting USA 1
NCT04072458 Phase I BP1002 A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies Recruiting USA 0
NCT04074746 Phase I Cyclophosphamide + Fludarabine AFM13 Modified Immune Cells (AFM13-NK) and A Monoclonal Antibody (AFM13) in Treating Patients With Recurrent or Refractory CD30 Positive Hodgkin or Non-Hodgkin Lymphomas Active, not recruiting USA 0
NCT04083495 Phase II ATLCAR.CD30 cells CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma Recruiting USA 0
NCT04101331 Phase II AFM13 Phase II Study to Assess AFM13 in Patients With R/R CD30-positive T-cell Lymphoma or Transformed Mycosis Fungoides (REDIRECT) Completed USA | TUR | POL | ITA | FRA | ESP | DEU | AUS 2
NCT04105010 Phase II Golidocitinib Assessing An Oral Janus Kinase Inhibitor, AZD4205 as Monotherapy in Patients Who Have PTCL (JACKPOT8) Completed USA | AUS 2
NCT04136275 Phase I Anti-CD37 CAR T cells CAR-37 T Cells In Hematologic Malignancies Completed USA 0
NCT04217317 Phase II Bendamustine + CPI-613 CPI-613 in Combination With Bendamustine in Patients With Relapsed/Refractory T-Cell Non-Hodgkin Lymphoma Terminated USA 0
NCT04234048 Phase I Fenretinide Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/Refractory T-cell Non-Hodgkin Lymphoma Recruiting USA 0
NCT04254107 Phase I SGN-TGT Pembrolizumab + SGN-TGT A Safety Study of SGN-TGT in Patients With Advanced Cancer Terminated USA | ITA | GBR | FRA | ESP | CAN 0
NCT04334174 Phase II Brentuximab vedotin Study of Brentuximab Vedotin as Therapy After Autologous Stem Cell Transplant in Cluster of Differentiation Antigen 30 (CD30) Positive Peripheral TCell Lymphomas (BRENTICON-T) Withdrawn USA 0
NCT04464798 Phase I Iberdomide Iberdomide + Obinutuzumab Iberdomide + Rituximab A Dose Finding and Safety Study of CC-220, Alone and in Combination With an Anti-CD20 Monoclonal Antibody (mAb) in Subjects With Relapsed or Refractory Lymphomas Active, not recruiting USA | ITA | FRA | DEU 2
NCT04569032 Phase II Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Prednisone A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression Active, not recruiting USA | ITA | GBR | FRA | ESP | CZE 0
NCT04639843 Phase I Azacitidine + Doxorubicin + Duvelisib + Romidepsin Doxorubicin, CC-(486) (5-azacitidine), Romidepsin, and Duvelisib (hARD) for T-cell Lymphoma Withdrawn USA 0
NCT04653649 Phase Ib/II HSP-CAR30 CAR T-cells Against CD30 (HSP-CAR30) for Relapsed/ Refractory Hodgkin and T-cell Lymphoma. Unknown status ESP 0
NCT04703192 Phase II DS-3201b Valemetostat Tosylate (DS-3201b), an Enhancer of Zeste Homolog (EZH) 1/2 Dual Inhibitor, for Relapsed/Refractory Peripheral T-Cell Lymphoma (VALENTINE-PTCL01) Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUS 3
NCT04747236 Phase II Pralatrexate Belinostat Azacitidine + Romidepsin Gemcitabine Romidepsin A Randomized, Phase IIB, Multicenter, Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in Patients With Relapse or Refractory Peripheral T-cell Lymphoma (PTCL) Recruiting USA 0
NCT04771572 Phase I LP-118 Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL. Recruiting USA 0
NCT04774068 Phase I Romidepsin Parsaclisib + Romidepsin Romidepsin and Parsaclisib for the Treatment of Relapsed or Refractory T-Cell Lymphomas Active, not recruiting USA 0
NCT04795869 Phase II Brentuximab vedotin + Pembrolizumab Brentuximab Vedotin and Pembrolizumab in Treating Patients With Recurrent Peripheral T-Cell Lymphoma Withdrawn USA 0
NCT04803201 Phase II Cyclophosphamide + Doxorubicin + Duvelisib + Etoposide + Prednisone + Vincristine Sulfate Azacitidine + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma Recruiting USA 0
NCT04858256 Phase II Pacritinib Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms Recruiting USA 0
NCT04984837 Phase II Gemcitabine + Oxaliplatin Gemcitabine + Lacutamab + Oxaliplatin Study of Lacutamab in Peripheral T-cell Lymphoma Recruiting FRA | ESP | DEU | BEL 0
NCT05006664 Phase II Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone Brentuximab Vedotin in Combination With CHEP in Patient With PTCL Unknown status CZE 0
NCT05010005 Phase I Duvelisib + Ruxolitinib A Study of Ruxolitinib and Duvelisib in People With Lymphoma Active, not recruiting USA 0
NCT05011058 Phase II CHR-3996 CHR-3996 + Valganciclovir An Open-Label, Phase 2 Trial of Nanatinostat in Combination With Valganciclovir in Patients With Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas (NAVAL-1) Recruiting USA | ITA | ISR | GBR | FRA | ESP | DEU | CAN | BRA | AUS 5
NCT05079282 Phase I ONO-4685 Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma Recruiting USA 0
NCT05138458 Phase Ib/II Cyclophosphamide + Fludarabine + MT-101 MT-101 A Study of MT-101 in Subjects With CD5+ Relapsed/Refractory TCL (IMAGINE) Suspended USA 0
NCT05140382 Phase II AZD4573 AZD4573 as Monotherapy or in Combinations With Anti-cancer Agents in Patients With r/r PTCL or r/r cHL Completed USA | SWE | ITA | GBR | FRA | AUS 2
NCT05239910 Phase II Cyclophosphamide + Doxorubicin + Prednisone + Tenalisib + Vincristine Sulfate Study to Evaluate the Efficacy and Safety of Tenalisib, Given With CHOP Therapy for Front Line Treatment in Patients With PTCL Withdrawn USA 0
NCT05274997 Phase II Linperlisib A Phase II Study of Linperlisib (YY-20394) in Patients With Relapsed or Refractory Peripheral T/NK Cell Lymphoma Unknown status USA 0
NCT05321147 Phase I Lacutamab Safety and Efficacy of Lacutamab in Patients With Relapsed/Refractory Peripheral T-cell Lymphoma That Express KIR3DL2 Completed USA 1
NCT05346809 Phase II Isatuximab Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma Recruiting USA 0
NCT05358379 Phase Ib/II CYC140 A Study to Investigate CYC140, in Subjects With Advanced Solid Tumors and Lymphoma Recruiting USA | ESP 1
NCT05371054 Phase Ib/II Prednisone + Venetoclax + VIP152 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid Malignancies Recruiting USA 0
NCT05377827 Phase I WU-CART-007 Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of Anti-CD7 Allogeneic CAR T-Cells (WU-CART-007) in Patients With CD7+ Hematologic Malignancies Active, not recruiting USA 0
NCT05883449 Phase II AB-101 + AFM13 Aldesleukin Cyclophosphamide + Fludarabine Phase 2 Study of AFM13 in Combination With AB-101 in Subjects With R/R HL and CD30+ PTCL (LuminICE-203) Recruiting USA 0
NCT05967416 Phase I SIRPant-M Phase 1, Open-Label Study of SIRPant-M in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma Recruiting USA 0
NCT05983965 Phase I Tazemetostat Acalabrutinib + Tazemetostat Study of Tazemetostat in Lymphoid Malignancies Recruiting USA 0
NCT06072131 Phase III Cyclophosphamide + Doxorubicin + Prednisone + Vincristine Sulfate Cyclophosphamide + Pralatrexate + Prednisone + Vincristine Sulfate Belinostat + Cyclophosphamide + Doxorubicin + Prednisone + Vincristine Sulfate To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL (CRESCENDO) Recruiting USA | POL | HUN 2
NCT06120504 Phase I SGN-35T A Safety Study of SGN-35T in Adults With Advanced Cancers Recruiting USA | GBR | ESP | DNK | CAN 0
NCT06176690 Phase I C7R.CD30.CAR-EBVS T-cells Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas Not yet recruiting USA 0
NCT06254495 Phase I SGN-35C A Safety Study of SGN-35C in Adults With Advanced Cancers Recruiting USA | ITA | DNK 0
NCT06420089 Phase I Cyclophosphamide + Fludarabine + Senza5 CART5 Senza5 CART5 CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) for T Cell Non-Hodgkin Lymphoma (NHL) (VIPER101) Recruiting USA 0
NCT06492304 Phase Ib/II CTX131 A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed/Refractory Hematologic Malignancies Recruiting USA 0
NCT06508463 Phase I Cemiplimab + Ipilimumab + VSV-hIFNbeta-NIS Intravenous Vesicular Stomatitis Virus in Patients With Peripheral T-cell Lymphoma Recruiting USA 0
NCT06561048 Phase III Pralatrexate CPI-818 Belinostat Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma Recruiting USA 0
NCT06630091 Phase II Cyclophosphamide + Doxorubicin + Golidocitinib + Prednisone + Vincristine Sulfate A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study Not yet recruiting USA 0