TP53: Gene Detail - Cancer Knowledgebase (CKB)

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Gene Symbol

TP53

Synonyms

BCC7 | BMFS5 | LFS1 | P53 | TRP53

Gene Description

TP53, tumor protein p53, is a tumor suppressor (PMID: 30562755) and oncogene (PMID: 30577483) involved in cell cycle arrest and apoptosis, and is the most frequently mutated gene in cancer (PMID: 10065147, PMID: 22713868). TP53 germline mutations are common in Li-Fraumeni syndrome (PMID: 30239254) and somatic missense mutations are frequent in almost all cancer types (PMID: 30224644) and are also implicated in chemoresistance (PMID: 9927204, PMID: 24065105, PMID: 27066457).

ACMG Incidental List v3.0:

Yes, Li-Fraumeni syndrome (PMID: 34012068)

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
7157	17	17p13.1	NM_000546	Both: Oncogene and Tumor suppressor (PMID: 30606230)

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Spaces will be interpreted literally in the search. Use the percentage character '%' as a wildcard to search for multiple values
When searching for values delimited by '%', searches are ordered by their appearance in the text. (i.e. 'A%C' will likely return different results than 'C%A')
Precede text with a caret '^' to indicate search should "start with" the text
Follow text with a dollar sign '$' to indicate search should "end with" the preceding text

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

TP53 - Gene Detail